Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats

Post-weaning protein malnutrition is often related to the development of cardiovascular and metabolic diseases in humans, as well to changed content of neurotransmitters in the central nervous system under experimental conditions. The rostral ventrolateral medulla (RVLM) is a bulbar region that cont...

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Autores principales:	Rodrigues,Fabiana Aparecida, Chianca-Jr,Deoclecio Alves, Gonçalves Fernandes,Luciano
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	baroreflex blood pressure L-glutamate receptors heart rate malnutrition RVLM
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400002
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spelling	oai:scielo:S0716-976020120004000022013-03-15Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake ratsRodrigues,Fabiana AparecidaChianca-Jr,Deoclecio AlvesGonçalves Fernandes,Luciano baroreflex blood pressure L-glutamate receptors heart rate malnutrition RVLM Post-weaning protein malnutrition is often related to the development of cardiovascular and metabolic diseases in humans, as well to changed content of neurotransmitters in the central nervous system under experimental conditions. The rostral ventrolateral medulla (RVLM) is a bulbar region that contains sympathetic premotor neurons; the excitatory amino acid L-glutamate seems to be the main neurotransmitter at this level. The aim of the present study was to evaluate the possible change in the L-glutamate sensitivity of the RVLM neurons of malnourished animals. Male Fischer rats were divided into two groups: control (n = 15) and malnourished (n = 19). Four days before the experiments, guide cannulas were implanted bilaterally in direction of the RVLM for microinjection of L-glutamate. Twenty-four hours before the experiments, the femoral artery was cannulated for cardiovascular recordings. The results showed that the baseline heart rate increased in malnourished compared to control animals (412.18 ± 16.03 bpm vs. 370.74 ± 9.59 bpm, respectively). Malnourished animals presented a dissimilar concentration-dependent pressor response curve to L-glutamate and an attenuated baroreflex gain. Our results suggest that post-weaning protein restriction affects glutamatergic neurotransmission of the baroreflex at the RVLM level.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400002en10.4067/S0716-97602012000400002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	baroreflex blood pressure L-glutamate receptors heart rate malnutrition RVLM
spellingShingle	baroreflex blood pressure L-glutamate receptors heart rate malnutrition RVLM Rodrigues,Fabiana Aparecida Chianca-Jr,Deoclecio Alves Gonçalves Fernandes,Luciano Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
description	Post-weaning protein malnutrition is often related to the development of cardiovascular and metabolic diseases in humans, as well to changed content of neurotransmitters in the central nervous system under experimental conditions. The rostral ventrolateral medulla (RVLM) is a bulbar region that contains sympathetic premotor neurons; the excitatory amino acid L-glutamate seems to be the main neurotransmitter at this level. The aim of the present study was to evaluate the possible change in the L-glutamate sensitivity of the RVLM neurons of malnourished animals. Male Fischer rats were divided into two groups: control (n = 15) and malnourished (n = 19). Four days before the experiments, guide cannulas were implanted bilaterally in direction of the RVLM for microinjection of L-glutamate. Twenty-four hours before the experiments, the femoral artery was cannulated for cardiovascular recordings. The results showed that the baseline heart rate increased in malnourished compared to control animals (412.18 ± 16.03 bpm vs. 370.74 ± 9.59 bpm, respectively). Malnourished animals presented a dissimilar concentration-dependent pressor response curve to L-glutamate and an attenuated baroreflex gain. Our results suggest that post-weaning protein restriction affects glutamatergic neurotransmission of the baroreflex at the RVLM level.
author	Rodrigues,Fabiana Aparecida Chianca-Jr,Deoclecio Alves Gonçalves Fernandes,Luciano
author_facet	Rodrigues,Fabiana Aparecida Chianca-Jr,Deoclecio Alves Gonçalves Fernandes,Luciano
author_sort	Rodrigues,Fabiana Aparecida
title	Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
title_short	Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
title_full	Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
title_fullStr	Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
title_full_unstemmed	Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats
title_sort	malnutrition affects the pressor response to microinjection of l-glutamate into the rvlm of awake rats
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400002
work_keys_str_mv	AT rodriguesfabianaaparecida malnutritionaffectsthepressorresponsetomicroinjectionoflglutamateintothervlmofawakerats AT chiancajrdeoclecioalves malnutritionaffectsthepressorresponsetomicroinjectionoflglutamateintothervlmofawakerats AT goncalvesfernandesluciano malnutritionaffectsthepressorresponsetomicroinjectionoflglutamateintothervlmofawakerats
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Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats

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