IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women

Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women. The aim of this study is to determine whether the expression of IGF2 is associated wit...

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Autores principales:	Ru-Fei,Gao, Xue-Qing,Liu, Ying-Xiong,Wang, Xue-Mei,Chen, Yu-Bin,Ding, Jun-Lin,He
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	Insulin-like growth factor 2 loss of imprinting retention of imprinting pregnancy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400004
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spelling	oai:scielo:S0716-976020120004000042013-03-15IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese womenRu-Fei,GaoXue-Qing,LiuYing-Xiong,WangXue-Mei,ChenYu-Bin,DingJun-Lin,He Insulin-like growth factor 2 loss of imprinting retention of imprinting pregnancy Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women. The aim of this study is to determine whether the expression of IGF2 is associated with its imprinting status in healthy Chinese pregnant women. The IGF2 imprinting status of 300 pregnant women was analyzed. 20 cases of IGF2 LOI and 20 cases of IGF2 retention of imprinting (ROI) were selected randomly for IGF2 expression analysis. The expression pattern of IGF2 between the group with IGF2 ROI and group with IGF2 LOI in healthy Chinese pregnant women was evaluated by real time PCR and western blot. The result showed no significant differences between IGF2 ROI and LOI groups in mRNA and protein levels. These results imply that IGF2 imprinting status has no obvious impact on its expression. There may be some unknown important factors other than imprinting status driving IGF2 expression.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400004en10.4067/S0716-97602012000400004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Insulin-like growth factor 2 loss of imprinting retention of imprinting pregnancy
spellingShingle	Insulin-like growth factor 2 loss of imprinting retention of imprinting pregnancy Ru-Fei,Gao Xue-Qing,Liu Ying-Xiong,Wang Xue-Mei,Chen Yu-Bin,Ding Jun-Lin,He IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
description	Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women. The aim of this study is to determine whether the expression of IGF2 is associated with its imprinting status in healthy Chinese pregnant women. The IGF2 imprinting status of 300 pregnant women was analyzed. 20 cases of IGF2 LOI and 20 cases of IGF2 retention of imprinting (ROI) were selected randomly for IGF2 expression analysis. The expression pattern of IGF2 between the group with IGF2 ROI and group with IGF2 LOI in healthy Chinese pregnant women was evaluated by real time PCR and western blot. The result showed no significant differences between IGF2 ROI and LOI groups in mRNA and protein levels. These results imply that IGF2 imprinting status has no obvious impact on its expression. There may be some unknown important factors other than imprinting status driving IGF2 expression.
author	Ru-Fei,Gao Xue-Qing,Liu Ying-Xiong,Wang Xue-Mei,Chen Yu-Bin,Ding Jun-Lin,He
author_facet	Ru-Fei,Gao Xue-Qing,Liu Ying-Xiong,Wang Xue-Mei,Chen Yu-Bin,Ding Jun-Lin,He
author_sort	Ru-Fei,Gao
title	IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
title_short	IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
title_full	IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
title_fullStr	IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
title_full_unstemmed	IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women
title_sort	igf2 expression in blood is not associated with its imprinting status in healthy pregnant chinese women
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400004
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IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women

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