lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population

BACKGROUND: Studies have demonstrated that some polymorphisms in different interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS AND METHODS: A case...

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Autores principales:	Felipe,Aledson V, Silva,Tiago D, Pimenta,Célia A, Kassab,Paulo, Forones,Nora M
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	IL-8 polymorphism gastric cancer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400007
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spelling	oai:scielo:S0716-976020120004000072013-03-15lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian populationFelipe,Aledson VSilva,Tiago DPimenta,Célia AKassab,PauloForones,Nora M IL-8 polymorphism gastric cancer BACKGROUND: Studies have demonstrated that some polymorphisms in different interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS AND METHODS: A case-control study was conducted on patients with noncardia gastric cancer. DNA was extracted from leukocytes and the IL-8 (rs4073) -251A/T polymorphism was analyzed by PCR-RFLP. Infection with Helicobacter pylori was investigated in the serum by ELISA. RESULTS: The sample consisted of 104 patients with GC and 196 controls. Cigarette smoking (P=0.007) and high fat intake (P=0.01) were more frequent in patients with GC. The proportion of patients infected with H. pylori was similar in the two groups (P=0.101). The frequency of the genotype A/T was higher in the cancer group (P=0.008). An increased risk of GC was found in subjects carrying the genotype A/T (OR=2.50, CI: 1.27-4.90), subjects with high fat intake (OR=1.92, CI: 1.17-3.15), and smokers (OR=2.00, CI: 1.203.31). CONCLUSIONS: Subjects with the heterozygous A/T genotype, high fat intake and smokers or ex-smokers presented an increased risk of GC. Individuals with A/A genotype may have protective effect for GC.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400007en10.4067/S0716-97602012000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	IL-8 polymorphism gastric cancer
spellingShingle	IL-8 polymorphism gastric cancer Felipe,Aledson V Silva,Tiago D Pimenta,Célia A Kassab,Paulo Forones,Nora M lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
description	BACKGROUND: Studies have demonstrated that some polymorphisms in different interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS AND METHODS: A case-control study was conducted on patients with noncardia gastric cancer. DNA was extracted from leukocytes and the IL-8 (rs4073) -251A/T polymorphism was analyzed by PCR-RFLP. Infection with Helicobacter pylori was investigated in the serum by ELISA. RESULTS: The sample consisted of 104 patients with GC and 196 controls. Cigarette smoking (P=0.007) and high fat intake (P=0.01) were more frequent in patients with GC. The proportion of patients infected with H. pylori was similar in the two groups (P=0.101). The frequency of the genotype A/T was higher in the cancer group (P=0.008). An increased risk of GC was found in subjects carrying the genotype A/T (OR=2.50, CI: 1.27-4.90), subjects with high fat intake (OR=1.92, CI: 1.17-3.15), and smokers (OR=2.00, CI: 1.203.31). CONCLUSIONS: Subjects with the heterozygous A/T genotype, high fat intake and smokers or ex-smokers presented an increased risk of GC. Individuals with A/A genotype may have protective effect for GC.
author	Felipe,Aledson V Silva,Tiago D Pimenta,Célia A Kassab,Paulo Forones,Nora M
author_facet	Felipe,Aledson V Silva,Tiago D Pimenta,Célia A Kassab,Paulo Forones,Nora M
author_sort	Felipe,Aledson V
title	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
title_short	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
title_full	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
title_fullStr	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
title_full_unstemmed	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
title_sort	lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400007
work_keys_str_mv	AT felipealedsonv lnterleukin8genepolymorphismandsusceptibilitytogastriccancerinabrazilianpopulation AT silvatiagod lnterleukin8genepolymorphismandsusceptibilitytogastriccancerinabrazilianpopulation AT pimentaceliaa lnterleukin8genepolymorphismandsusceptibilitytogastriccancerinabrazilianpopulation AT kassabpaulo lnterleukin8genepolymorphismandsusceptibilitytogastriccancerinabrazilianpopulation AT foronesnoram lnterleukin8genepolymorphismandsusceptibilitytogastriccancerinabrazilianpopulation
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lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population

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