Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

Leishamaniasis is a disease that affects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Mo...

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Autores principales:	Farias-Junior,Paulo A, Rios,Marcos C, Moura,Tauanny A, Almeida,Roque P, Alves,Pericles B, Blank,Arie F, Fernandes,Roberta P M, Scher,Ricardo
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	carvacrol p-cymene essential oil composition Leishmania chagasi Lippia ssp. thymol Verbenaceae
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400012
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spelling	oai:scielo:S0716-976020120004000122013-03-15Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides ChamFarias-Junior,Paulo ARios,Marcos CMoura,Tauanny AAlmeida,Roque PAlves,Pericles BBlank,Arie FFernandes,Roberta P MScher,Ricardo carvacrol p-cymene essential oil composition Leishmania chagasi Lippia ssp. thymol Verbenaceae Leishamaniasis is a disease that affects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal effects of a thymol- and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed significant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more effective, with IC50/72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400012en10.4067/S0716-97602012000400012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	carvacrol p-cymene essential oil composition Leishmania chagasi Lippia ssp. thymol Verbenaceae
spellingShingle	carvacrol p-cymene essential oil composition Leishmania chagasi Lippia ssp. thymol Verbenaceae Farias-Junior,Paulo A Rios,Marcos C Moura,Tauanny A Almeida,Roque P Alves,Pericles B Blank,Arie F Fernandes,Roberta P M Scher,Ricardo Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
description	Leishamaniasis is a disease that affects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal effects of a thymol- and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed significant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more effective, with IC50/72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds.
author	Farias-Junior,Paulo A Rios,Marcos C Moura,Tauanny A Almeida,Roque P Alves,Pericles B Blank,Arie F Fernandes,Roberta P M Scher,Ricardo
author_facet	Farias-Junior,Paulo A Rios,Marcos C Moura,Tauanny A Almeida,Roque P Alves,Pericles B Blank,Arie F Fernandes,Roberta P M Scher,Ricardo
author_sort	Farias-Junior,Paulo A
title	Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
title_short	Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
title_full	Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
title_fullStr	Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
title_full_unstemmed	Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham
title_sort	leishmanicidal activity of carvacrol-rich essential oil from lippia sidoides cham
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400012
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Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

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