Exosomes: mediators of communication in eukaryotes

In addition to the established mechanisms of intercellular signaling, a new way of communication has gained much attention in the last decade: communication mediated by exosomes. Exosomes are nanovesicles (with a diameter of 40-120 nm) secreted into the extracellular space by the multivesicular endo...

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Autores principales:	Lopez-Verrilli,María A, Court,Felipe A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2013
Materias:	Exosome nanovesicle intercellular communication
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100001
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spelling	oai:scielo:S0716-976020130001000012014-09-08Exosomes: mediators of communication in eukaryotesLopez-Verrilli,María ACourt,Felipe A Exosome nanovesicle intercellular communication In addition to the established mechanisms of intercellular signaling, a new way of communication has gained much attention in the last decade: communication mediated by exosomes. Exosomes are nanovesicles (with a diameter of 40-120 nm) secreted into the extracellular space by the multivesicular endosome after its outer membrane fuses with the plasma membrane. Once released, exosomes modulate the response of the recipient cells that recognize them. This indicates that exosomes operate in a specific manner and participate in the regulation of the target cell. Remarkably, exosomes occur from unicellular organisms to mammals, suggesting an evolutionarily conserved mechanism of communication. In this review we describe the cascade of exosome formation, intracellular traffic, secretion, and internalization by recipient cells, and review their most relevant effects. We also highlight important steps that are still poorly understood.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100001en10.4067/S0716-97602013000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Exosome nanovesicle intercellular communication
spellingShingle	Exosome nanovesicle intercellular communication Lopez-Verrilli,María A Court,Felipe A Exosomes: mediators of communication in eukaryotes
description	In addition to the established mechanisms of intercellular signaling, a new way of communication has gained much attention in the last decade: communication mediated by exosomes. Exosomes are nanovesicles (with a diameter of 40-120 nm) secreted into the extracellular space by the multivesicular endosome after its outer membrane fuses with the plasma membrane. Once released, exosomes modulate the response of the recipient cells that recognize them. This indicates that exosomes operate in a specific manner and participate in the regulation of the target cell. Remarkably, exosomes occur from unicellular organisms to mammals, suggesting an evolutionarily conserved mechanism of communication. In this review we describe the cascade of exosome formation, intracellular traffic, secretion, and internalization by recipient cells, and review their most relevant effects. We also highlight important steps that are still poorly understood.
author	Lopez-Verrilli,María A Court,Felipe A
author_facet	Lopez-Verrilli,María A Court,Felipe A
author_sort	Lopez-Verrilli,María A
title	Exosomes: mediators of communication in eukaryotes
title_short	Exosomes: mediators of communication in eukaryotes
title_full	Exosomes: mediators of communication in eukaryotes
title_fullStr	Exosomes: mediators of communication in eukaryotes
title_full_unstemmed	Exosomes: mediators of communication in eukaryotes
title_sort	exosomes: mediators of communication in eukaryotes
publisher	Sociedad de Biología de Chile
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100001
work_keys_str_mv	AT lopezverrillimariaa exosomesmediatorsofcommunicationineukaryotes AT courtfelipea exosomesmediatorsofcommunicationineukaryotes
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Exosomes: mediators of communication in eukaryotes

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