Regional density of glial cells in the rat corpus callosum

Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of a...

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Autores principales:	Reyes-Haro,Daniel, Mora-Loyola,Ernesto, Soria-Ortiz,Berenice, García-Colunga,Jesús
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2013
Materias:	Astrocytes corpus callosum genu glial cells splenium
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100004
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spelling	oai:scielo:S0716-976020130001000042014-09-08Regional density of glial cells in the rat corpus callosumReyes-Haro,DanielMora-Loyola,ErnestoSoria-Ortiz,BereniceGarcía-Colunga,Jesús Astrocytes corpus callosum genu glial cells splenium Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of axons have been previously described. Whether glial cell density varies accordingly is unknown; thus the aim of this study was to estimate glial cell density for the genu, body and splenium -the three main regions of CC-, of P6 and P30 rats. Here we report that the density of CC glial cells reduced by ~10% from P6 to P30. Even so, the density of astrocytes showed a slight increase (+6%), probably due to differentiation of glioblasts. Interestingly, glial cell density decreased for the genu (-21%) and the body (-13%), while for the splenium a minor increase (+5%) was observed. The astrocyte/glia ratio increased (from P6 to P30) for the genu (+27%), body (+17%) and splenium (+4%). Together, our results showed regional differences in glial cell density of the CC. Whether this pattern is modified in some neuropathologies remains to be explored.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100004en10.4067/S0716-97602013000100004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Astrocytes corpus callosum genu glial cells splenium
spellingShingle	Astrocytes corpus callosum genu glial cells splenium Reyes-Haro,Daniel Mora-Loyola,Ernesto Soria-Ortiz,Berenice García-Colunga,Jesús Regional density of glial cells in the rat corpus callosum
description	Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of axons have been previously described. Whether glial cell density varies accordingly is unknown; thus the aim of this study was to estimate glial cell density for the genu, body and splenium -the three main regions of CC-, of P6 and P30 rats. Here we report that the density of CC glial cells reduced by ~10% from P6 to P30. Even so, the density of astrocytes showed a slight increase (+6%), probably due to differentiation of glioblasts. Interestingly, glial cell density decreased for the genu (-21%) and the body (-13%), while for the splenium a minor increase (+5%) was observed. The astrocyte/glia ratio increased (from P6 to P30) for the genu (+27%), body (+17%) and splenium (+4%). Together, our results showed regional differences in glial cell density of the CC. Whether this pattern is modified in some neuropathologies remains to be explored.
author	Reyes-Haro,Daniel Mora-Loyola,Ernesto Soria-Ortiz,Berenice García-Colunga,Jesús
author_facet	Reyes-Haro,Daniel Mora-Loyola,Ernesto Soria-Ortiz,Berenice García-Colunga,Jesús
author_sort	Reyes-Haro,Daniel
title	Regional density of glial cells in the rat corpus callosum
title_short	Regional density of glial cells in the rat corpus callosum
title_full	Regional density of glial cells in the rat corpus callosum
title_fullStr	Regional density of glial cells in the rat corpus callosum
title_full_unstemmed	Regional density of glial cells in the rat corpus callosum
title_sort	regional density of glial cells in the rat corpus callosum
publisher	Sociedad de Biología de Chile
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100004
work_keys_str_mv	AT reyesharodaniel regionaldensityofglialcellsintheratcorpuscallosum AT moraloyolaernesto regionaldensityofglialcellsintheratcorpuscallosum AT soriaortizberenice regionaldensityofglialcellsintheratcorpuscallosum AT garciacolungajesus regionaldensityofglialcellsintheratcorpuscallosum
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Regional density of glial cells in the rat corpus callosum

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