High gender -specific susceptibility to curare- a neuromuscular blocking agent

Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecti...

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Autores principales:	Maurya,Santosh K, Periasamy,Muthu, Bal,Naresh C
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2013
Materias:	Curare dose response gender muscle activity oxygen consumption
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100011
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spelling	oai:scielo:S0716-976020130001000112014-09-08High gender -specific susceptibility to curare- a neuromuscular blocking agentMaurya,Santosh KPeriasamy,MuthuBal,Naresh C Curare dose response gender muscle activity oxygen consumption Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, but at higher doses it is known to be lethal. However, the exact dose of curare initiating muscle relaxation vs. lethal effect has not been fully characterized in mice. In this study we carefully examined the dose-response for achieving muscle inactivity over lethality in both male and female mice (C57BL6/J). The most striking finding of this study is that female mice were highly susceptible to curare; both the EDm and LDm were at least 3-fold lower than male littermates. This study shows that gender-specific differences can be an important factor when administering skeletal muscle relaxants, particularly curare or other analogous agents targeted to the neuromuscular junction.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100011en10.4067/S0716-97602013000100011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Curare dose response gender muscle activity oxygen consumption
spellingShingle	Curare dose response gender muscle activity oxygen consumption Maurya,Santosh K Periasamy,Muthu Bal,Naresh C High gender -specific susceptibility to curare- a neuromuscular blocking agent
description	Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, but at higher doses it is known to be lethal. However, the exact dose of curare initiating muscle relaxation vs. lethal effect has not been fully characterized in mice. In this study we carefully examined the dose-response for achieving muscle inactivity over lethality in both male and female mice (C57BL6/J). The most striking finding of this study is that female mice were highly susceptible to curare; both the EDm and LDm were at least 3-fold lower than male littermates. This study shows that gender-specific differences can be an important factor when administering skeletal muscle relaxants, particularly curare or other analogous agents targeted to the neuromuscular junction.
author	Maurya,Santosh K Periasamy,Muthu Bal,Naresh C
author_facet	Maurya,Santosh K Periasamy,Muthu Bal,Naresh C
author_sort	Maurya,Santosh K
title	High gender -specific susceptibility to curare- a neuromuscular blocking agent
title_short	High gender -specific susceptibility to curare- a neuromuscular blocking agent
title_full	High gender -specific susceptibility to curare- a neuromuscular blocking agent
title_fullStr	High gender -specific susceptibility to curare- a neuromuscular blocking agent
title_full_unstemmed	High gender -specific susceptibility to curare- a neuromuscular blocking agent
title_sort	high gender -specific susceptibility to curare- a neuromuscular blocking agent
publisher	Sociedad de Biología de Chile
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100011
work_keys_str_mv	AT mauryasantoshk highgenderspecificsusceptibilitytocurareaneuromuscularblockingagent AT periasamymuthu highgenderspecificsusceptibilitytocurareaneuromuscularblockingagent AT balnareshc highgenderspecificsusceptibilitytocurareaneuromuscularblockingagent
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High gender -specific susceptibility to curare- a neuromuscular blocking agent

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