DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia

DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia

DNA repair is one of the central defense mechanisms against mutagenic exposures. Inherited SNPs of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity...

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Autores principales: Alanazi,Mohammad, Pathan,Akbar Ali Khan, Ajaj,Sana Abdulla, Khan,Wajahatullah, Shaik,Jilani P, Al Tassan,Nada, Parine,Narasimha Reddy
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2013
Materias:
DNA Repair genes
polymorphism
Saudi population
XRCC1
XRCC3
OGG1
XPD
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200007
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spelling oai:scielo:S0716-976020130002000072013-08-19DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi ArabiaAlanazi,MohammadPathan,Akbar Ali KhanAjaj,Sana AbdullaKhan,WajahatullahShaik,Jilani PAl Tassan,NadaParine,Narasimha Reddy DNA Repair genes polymorphism Saudi population XRCC1 XRCC3 OGG1 XPD DNA repair is one of the central defense mechanisms against mutagenic exposures. Inherited SNPs of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. Saudi Arabia harbors enormous genetic and cultural diversity. In the present study we aimed to determine the genotype and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 386 healthy individuals residing in the central region of Saudi Arabia and compare them with HapMap and other populations. The genotype and allele frequencies of the four DNA repair gene loci in central Saudi population showed a distinctive pattern. Furthermore, comparison of polymorphisms in these genes with other populations also showed a unique pattern for the central Saudi population. To the best of our knowledge, this is the first report that deals with these DNA repair gene polymorphisms among the central Saudi population.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200007en10.4067/S0716-97602013000200007
institution Scielo Chile
collection Scielo Chile
language English
topic DNA Repair genes
polymorphism
Saudi population
XRCC1
XRCC3
OGG1
XPD
spellingShingle DNA Repair genes
polymorphism
Saudi population
XRCC1
XRCC3
OGG1
XPD
Alanazi,Mohammad
Pathan,Akbar Ali Khan
Ajaj,Sana Abdulla
Khan,Wajahatullah
Shaik,Jilani P
Al Tassan,Nada
Parine,Narasimha Reddy
DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
description DNA repair is one of the central defense mechanisms against mutagenic exposures. Inherited SNPs of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. Saudi Arabia harbors enormous genetic and cultural diversity. In the present study we aimed to determine the genotype and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 386 healthy individuals residing in the central region of Saudi Arabia and compare them with HapMap and other populations. The genotype and allele frequencies of the four DNA repair gene loci in central Saudi population showed a distinctive pattern. Furthermore, comparison of polymorphisms in these genes with other populations also showed a unique pattern for the central Saudi population. To the best of our knowledge, this is the first report that deals with these DNA repair gene polymorphisms among the central Saudi population.
author Alanazi,Mohammad
Pathan,Akbar Ali Khan
Ajaj,Sana Abdulla
Khan,Wajahatullah
Shaik,Jilani P
Al Tassan,Nada
Parine,Narasimha Reddy
author_facet Alanazi,Mohammad
Pathan,Akbar Ali Khan
Ajaj,Sana Abdulla
Khan,Wajahatullah
Shaik,Jilani P
Al Tassan,Nada
Parine,Narasimha Reddy
author_sort Alanazi,Mohammad
title DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
title_short DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
title_full DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
title_fullStr DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
title_full_unstemmed DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
title_sort dna repair genes xrcc1, xrcc3, xpd, and ogg1 polymorphisms among the central region population of saudi arabia
publisher Sociedad de Biología de Chile
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200007
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