Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats
Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritio...
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Sociedad de Biología de Chile
2013
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oai:scielo:S0716-976020130002000112013-08-19Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation ratsLiu,ChongbinWang,RuiZhang,BoHu,ChenZhang,Hong Autophagy iron supplementation lycopene oxidative stress proliferation Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confirm its intervention in these defence mechanisms. We found that iron supplementation induced cell proliferation predominantly in non parenchymal cells compared with hepatocytes, but not apoptosis. In addition, iron was accumulated within the hepatic lysosomes where it triggered autophagy as evidenced by the formation of autophagic vesicles detected by LC3-B staining. Iron supplementation also induced morphologic alterations of the mitochondrial membranes probably due to increased lipid peroxidation as indicated by elevated iron and malondialdehyde concentrations in serum and tissues. Lycopene reduced iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level in the liver and colon and enhancing the total superoxide dismutase activities in serum and tissues. The result suggest that lycopene prevents iron-induced oxidative stress, proliferation and autophagy at both biochemical and histological levels due to its potent free radical scavenging and antioxidant properties.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200011en10.4067/S0716-97602013000200011 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Autophagy iron supplementation lycopene oxidative stress proliferation |
| spellingShingle |
Autophagy iron supplementation lycopene oxidative stress proliferation Liu,Chongbin Wang,Rui Zhang,Bo Hu,Chen Zhang,Hong Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| description |
Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confirm its intervention in these defence mechanisms. We found that iron supplementation induced cell proliferation predominantly in non parenchymal cells compared with hepatocytes, but not apoptosis. In addition, iron was accumulated within the hepatic lysosomes where it triggered autophagy as evidenced by the formation of autophagic vesicles detected by LC3-B staining. Iron supplementation also induced morphologic alterations of the mitochondrial membranes probably due to increased lipid peroxidation as indicated by elevated iron and malondialdehyde concentrations in serum and tissues. Lycopene reduced iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level in the liver and colon and enhancing the total superoxide dismutase activities in serum and tissues. The result suggest that lycopene prevents iron-induced oxidative stress, proliferation and autophagy at both biochemical and histological levels due to its potent free radical scavenging and antioxidant properties. |
| author |
Liu,Chongbin Wang,Rui Zhang,Bo Hu,Chen Zhang,Hong |
| author_facet |
Liu,Chongbin Wang,Rui Zhang,Bo Hu,Chen Zhang,Hong |
| author_sort |
Liu,Chongbin |
| title |
Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| title_short |
Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| title_full |
Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| title_fullStr |
Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| title_full_unstemmed |
Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| title_sort |
protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2013 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200011 |
| work_keys_str_mv |
AT liuchongbin protectiveeffectsoflycopeneonoxidativestressproliferationandautophagyinironsupplementationrats AT wangrui protectiveeffectsoflycopeneonoxidativestressproliferationandautophagyinironsupplementationrats AT zhangbo protectiveeffectsoflycopeneonoxidativestressproliferationandautophagyinironsupplementationrats AT huchen protectiveeffectsoflycopeneonoxidativestressproliferationandautophagyinironsupplementationrats AT zhanghong protectiveeffectsoflycopeneonoxidativestressproliferationandautophagyinironsupplementationrats |
| _version_ |
1718441500652601344 |