Septin 7: Actin cross-organization is required for axonal association of Schwann cells

Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion...

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Autores principales:	Roth,Alejandro D, Liazoghli,Dalinda, Perez De Arce,Felipe, Colman,David R
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2013
Materias:	Axon wrapping Septins Myelination Schwann Cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300004
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spelling	oai:scielo:S0716-976020130003000042014-01-20Septin 7: Actin cross-organization is required for axonal association of Schwann cellsRoth,Alejandro DLiazoghli,DalindaPerez De Arce,FelipeColman,David R Axon wrapping Septins Myelination Schwann Cells Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.3 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300004en10.4067/S0716-97602013000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Axon wrapping Septins Myelination Schwann Cells
spellingShingle	Axon wrapping Septins Myelination Schwann Cells Roth,Alejandro D Liazoghli,Dalinda Perez De Arce,Felipe Colman,David R Septin 7: Actin cross-organization is required for axonal association of Schwann cells
description	Myelin sheaths present two distinct domains: compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.
author	Roth,Alejandro D Liazoghli,Dalinda Perez De Arce,Felipe Colman,David R
author_facet	Roth,Alejandro D Liazoghli,Dalinda Perez De Arce,Felipe Colman,David R
author_sort	Roth,Alejandro D
title	Septin 7: Actin cross-organization is required for axonal association of Schwann cells
title_short	Septin 7: Actin cross-organization is required for axonal association of Schwann cells
title_full	Septin 7: Actin cross-organization is required for axonal association of Schwann cells
title_fullStr	Septin 7: Actin cross-organization is required for axonal association of Schwann cells
title_full_unstemmed	Septin 7: Actin cross-organization is required for axonal association of Schwann cells
title_sort	septin 7: actin cross-organization is required for axonal association of schwann cells
publisher	Sociedad de Biología de Chile
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300004
work_keys_str_mv	AT rothalejandrod septin7actincrossorganizationisrequiredforaxonalassociationofschwanncells AT liazoghlidalinda septin7actincrossorganizationisrequiredforaxonalassociationofschwanncells AT perezdearcefelipe septin7actincrossorganizationisrequiredforaxonalassociationofschwanncells AT colmandavidr septin7actincrossorganizationisrequiredforaxonalassociationofschwanncells
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Septin 7: Actin cross-organization is required for axonal association of Schwann cells

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