Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation

Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin....

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Autores principales:	Montoya,Fredy, Martínez,Fernando, García-Robles,María, Balmaceda-Aguilera,Carolina, Koch,Ximena, Rodríguez,Federico, Silva-Álvarez,Carmen, Salazar,Katterine, Ulloa,Viviana, Nualart,Francisco
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2013
Materias:	Cartilage lesion microfracture stem cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015
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spelling	oai:scielo:S0716-976020130004000152014-02-05Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiationMontoya,FredyMartínez,FernandoGarcía-Robles,MaríaBalmaceda-Aguilera,CarolinaKoch,XimenaRodríguez,FedericoSilva-Álvarez,CarmenSalazar,KatterineUlloa,VivianaNualart,Francisco Cartilage lesion microfracture stem cells Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex organs, including vascular, cardiac or bone tissues, similar advances in tissue engineering for cartilage repair are lacking. Although the inherent characteristics of cartilage tissue, such as the lack of vascularity and low cellular diversity, suggest that it would be one of the more simple tissues to be engineered, its functional weight-bearing role and implant viability and adaptation make this type of repair more complex. Over the last decade several therapeutic approaches and innovative techniques show promise for lasting and functional regeneration of hyaline cartilage. Here we will analyze the main strategies for cartilage regeneration and discuss our experience.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.4 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015en10.4067/S0716-97602013000400015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cartilage lesion microfracture stem cells
spellingShingle	Cartilage lesion microfracture stem cells Montoya,Fredy Martínez,Fernando García-Robles,María Balmaceda-Aguilera,Carolina Koch,Ximena Rodríguez,Federico Silva-Álvarez,Carmen Salazar,Katterine Ulloa,Viviana Nualart,Francisco Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
description	Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex organs, including vascular, cardiac or bone tissues, similar advances in tissue engineering for cartilage repair are lacking. Although the inherent characteristics of cartilage tissue, such as the lack of vascularity and low cellular diversity, suggest that it would be one of the more simple tissues to be engineered, its functional weight-bearing role and implant viability and adaptation make this type of repair more complex. Over the last decade several therapeutic approaches and innovative techniques show promise for lasting and functional regeneration of hyaline cartilage. Here we will analyze the main strategies for cartilage regeneration and discuss our experience.
author	Montoya,Fredy Martínez,Fernando García-Robles,María Balmaceda-Aguilera,Carolina Koch,Ximena Rodríguez,Federico Silva-Álvarez,Carmen Salazar,Katterine Ulloa,Viviana Nualart,Francisco
author_facet	Montoya,Fredy Martínez,Fernando García-Robles,María Balmaceda-Aguilera,Carolina Koch,Ximena Rodríguez,Federico Silva-Álvarez,Carmen Salazar,Katterine Ulloa,Viviana Nualart,Francisco
author_sort	Montoya,Fredy
title	Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
title_short	Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
title_full	Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
title_fullStr	Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
title_full_unstemmed	Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
title_sort	clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
publisher	Sociedad de Biología de Chile
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015
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Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation

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