Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequenc...

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Autores principales:	Ramalho,Eduardo AVF, Silva-Filho,João LQ, Cartaxo,Marina FS, Cavalcanti,Carmelita BL, Rêgo,Moacyr JBM, Oliveira,Maria BM, Beltrão,Eduardo IC
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Breast cancer Epigenetics Metastasis Methylation Polymorphism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003
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spelling	oai:scielo:S0716-976020140001000032015-10-30Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast BrazilRamalho,Eduardo AVFSilva-Filho,João LQCartaxo,Marina FSCavalcanti,Carmelita BLRêgo,Moacyr JBMOliveira,Maria BMBeltrão,Eduardo IC Breast cancer Epigenetics Metastasis Methylation Polymorphism BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190). Regarding to polymorphism of codon 249 the frequency of Arg249 allele presented 82% which was considered not statistically significant. CONCLUSIONS: There was not statistical significance to BRCA2 promoter methylation with any parameters chosen. However, our findings suggest that patients who present heterozygous genotype at codon 72 of p53 gene may have a major susceptibility to any type of metastasis and this could serve as potential auxiliary biomarker for poor prognosis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003en10.1186/0717-6287-47-3
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Breast cancer Epigenetics Metastasis Methylation Polymorphism
spellingShingle	Breast cancer Epigenetics Metastasis Methylation Polymorphism Ramalho,Eduardo AVF Silva-Filho,João LQ Cartaxo,Marina FS Cavalcanti,Carmelita BL Rêgo,Moacyr JBM Oliveira,Maria BM Beltrão,Eduardo IC Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
description	BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190). Regarding to polymorphism of codon 249 the frequency of Arg249 allele presented 82% which was considered not statistically significant. CONCLUSIONS: There was not statistical significance to BRCA2 promoter methylation with any parameters chosen. However, our findings suggest that patients who present heterozygous genotype at codon 72 of p53 gene may have a major susceptibility to any type of metastasis and this could serve as potential auxiliary biomarker for poor prognosis.
author	Ramalho,Eduardo AVF Silva-Filho,João LQ Cartaxo,Marina FS Cavalcanti,Carmelita BL Rêgo,Moacyr JBM Oliveira,Maria BM Beltrão,Eduardo IC
author_facet	Ramalho,Eduardo AVF Silva-Filho,João LQ Cartaxo,Marina FS Cavalcanti,Carmelita BL Rêgo,Moacyr JBM Oliveira,Maria BM Beltrão,Eduardo IC
author_sort	Ramalho,Eduardo AVF
title	Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
title_short	Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
title_full	Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
title_fullStr	Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
title_full_unstemmed	Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil
title_sort	assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast brazil
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003
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Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

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