Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequenc...

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Autores principales: Ramalho,Eduardo AVF, Silva-Filho,João LQ, Cartaxo,Marina FS, Cavalcanti,Carmelita BL, Rêgo,Moacyr JBM, Oliveira,Maria BM, Beltrão,Eduardo IC
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2014
Materias:
Breast cancer
Epigenetics
Metastasis
Methylation
Polymorphism
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003
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