$Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction$
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Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction

BACKGROUND: Left ventricular diastolic dysfunction is one of the main characteristics of heart failure patients with a preserved left ventricular ejection fraction. As bilirubin is regarded as an important endogenous antioxidant molecule, serum total bilirubin levels were compared between heart fail...

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Autores principales:	Zheng,Huan, Li,Ye, Xie,Nanzi
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Bilirubin Heart failure Diastolic dysfunction Echocardiography
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100007
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spelling	oai:scielo:S0716-976020140001000072015-10-30Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fractionZheng,HuanLi,YeXie,Nanzi Bilirubin Heart failure Diastolic dysfunction Echocardiography BACKGROUND: Left ventricular diastolic dysfunction is one of the main characteristics of heart failure patients with a preserved left ventricular ejection fraction. As bilirubin is regarded as an important endogenous antioxidant molecule, serum total bilirubin levels were compared between heart failure patients with a preserved left ventricular ejection fraction and normal controls in this study. We recruited 327 heart failure patients with a preserved left ventricular ejection fraction and 200 healthy controls. Patients were divided into 4 subgroups by their comprehensive echocardiographic manifestations, 1-mild, 2-moderate, 3-severe (reversible restrictive), 4-severe (fixed restrictive). Total bilirubin levels were compared using stepwise multiple regressions adjusted for selected factors. RESULTS: After adjusting for gender, age, smoking, systolic blood pressure, diastolic blood pressure, total cholesterol and triglyceride, serum total bilirubin levels were significantly lower in the heart failure group compared with the control group (P < 0.01). Patients in the subgroup (4-severe) showed significantly (P < 0.05) lower levels of total bilirubin when compared with the subgroup (1-mild). CONCLUSIONS: TB level was negatively correlated with left ventricular diastolic dysfunction in heart failure patients with a preserved left ventricular ejection fraction, which might provide a new insight into the complicated mechanisms of heart failure with a preserved left ventricular ejection fraction.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100007en10.1186/0717-6287-47-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bilirubin Heart failure Diastolic dysfunction Echocardiography
spellingShingle	Bilirubin Heart failure Diastolic dysfunction Echocardiography Zheng,Huan Li,Ye Xie,Nanzi Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
description	BACKGROUND: Left ventricular diastolic dysfunction is one of the main characteristics of heart failure patients with a preserved left ventricular ejection fraction. As bilirubin is regarded as an important endogenous antioxidant molecule, serum total bilirubin levels were compared between heart failure patients with a preserved left ventricular ejection fraction and normal controls in this study. We recruited 327 heart failure patients with a preserved left ventricular ejection fraction and 200 healthy controls. Patients were divided into 4 subgroups by their comprehensive echocardiographic manifestations, 1-mild, 2-moderate, 3-severe (reversible restrictive), 4-severe (fixed restrictive). Total bilirubin levels were compared using stepwise multiple regressions adjusted for selected factors. RESULTS: After adjusting for gender, age, smoking, systolic blood pressure, diastolic blood pressure, total cholesterol and triglyceride, serum total bilirubin levels were significantly lower in the heart failure group compared with the control group (P < 0.01). Patients in the subgroup (4-severe) showed significantly (P < 0.05) lower levels of total bilirubin when compared with the subgroup (1-mild). CONCLUSIONS: TB level was negatively correlated with left ventricular diastolic dysfunction in heart failure patients with a preserved left ventricular ejection fraction, which might provide a new insight into the complicated mechanisms of heart failure with a preserved left ventricular ejection fraction.
author	Zheng,Huan Li,Ye Xie,Nanzi
author_facet	Zheng,Huan Li,Ye Xie,Nanzi
author_sort	Zheng,Huan
title	Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
title_short	Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
title_full	Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
title_fullStr	Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
title_full_unstemmed	Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
title_sort	association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100007
work_keys_str_mv	AT zhenghuan associationofserumtotalbilirubinlevelswithdiastolicdysfunctioninheartfailurewithpreservedejectionfraction AT liye associationofserumtotalbilirubinlevelswithdiastolicdysfunctioninheartfailurewithpreservedejectionfraction AT xienanzi associationofserumtotalbilirubinlevelswithdiastolicdysfunctioninheartfailurewithpreservedejectionfraction
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Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction

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