Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

BACKGROUND: Schistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been co...

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Autor principal:	Dkhi,Mohamed A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Schistosoma mansoni Berberine Liver Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100008
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spelling	oai:scielo:S0716-976020140001000082015-10-30Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in miceDkhi,Mohamed A Schistosoma mansoni Berberine Liver Mice BACKGROUND: Schistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice. RESULTS: S. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase. CONCLUSION: Based on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100008en10.1186/0717-6287-47-8
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Schistosoma mansoni Berberine Liver Mice
spellingShingle	Schistosoma mansoni Berberine Liver Mice Dkhi,Mohamed A Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
description	BACKGROUND: Schistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice. RESULTS: S. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase. CONCLUSION: Based on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.
author	Dkhi,Mohamed A
author_facet	Dkhi,Mohamed A
author_sort	Dkhi,Mohamed A
title	Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
title_short	Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
title_full	Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
title_fullStr	Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
title_full_unstemmed	Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
title_sort	role of berberine in ameliorating schistosoma mansoni-induced hepatic injury in mice
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100008
work_keys_str_mv	AT dkhimohameda roleofberberineinamelioratingschistosomamansoniinducedhepaticinjuryinmice
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Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

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