Immune enhancement activities of silk lutein extract from Bombyx mori cocoons

BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant sour...

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Autores principales:	Promphet,Porkaew, Bunarsa,Sirirat, Sutheerawattananonda,Manote, Kunthalert,Duangkamol
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Antibody production BALB/c mice Immune function Interleukin-2 Natural killer cells Silk lutein extract
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100015
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spelling	oai:scielo:S0716-976020140001000152015-10-30Immune enhancement activities of silk lutein extract from Bombyx mori cocoonsPromphet,PorkaewBunarsa,SiriratSutheerawattananonda,ManoteKunthalert,Duangkamol Antibody production BALB/c mice Immune function Interleukin-2 Natural killer cells Silk lutein extract BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined. RESULTS: Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable. CONCLUSIONS: Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100015en10.1186/0717-6287-47-15
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antibody production BALB/c mice Immune function Interleukin-2 Natural killer cells Silk lutein extract
spellingShingle	Antibody production BALB/c mice Immune function Interleukin-2 Natural killer cells Silk lutein extract Promphet,Porkaew Bunarsa,Sirirat Sutheerawattananonda,Manote Kunthalert,Duangkamol Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
description	BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined. RESULTS: Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable. CONCLUSIONS: Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.
author	Promphet,Porkaew Bunarsa,Sirirat Sutheerawattananonda,Manote Kunthalert,Duangkamol
author_facet	Promphet,Porkaew Bunarsa,Sirirat Sutheerawattananonda,Manote Kunthalert,Duangkamol
author_sort	Promphet,Porkaew
title	Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
title_short	Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
title_full	Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
title_fullStr	Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
title_full_unstemmed	Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
title_sort	immune enhancement activities of silk lutein extract from bombyx mori cocoons
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100015
work_keys_str_mv	AT promphetporkaew immuneenhancementactivitiesofsilkluteinextractfrombombyxmoricocoons AT bunarsasirirat immuneenhancementactivitiesofsilkluteinextractfrombombyxmoricocoons AT sutheerawattananondamanote immuneenhancementactivitiesofsilkluteinextractfrombombyxmoricocoons AT kunthalertduangkamol immuneenhancementactivitiesofsilkluteinextractfrombombyxmoricocoons
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Immune enhancement activities of silk lutein extract from Bombyx mori cocoons

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