The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA

BACKGROUND: We found a strong selective 3-sites periodicity of deviations from randomness of the dinucleotide (DN) distribution, where both bases of DN were separated by 1, 2, K sites in prokaryotes and mtDNA. Three main aspects are studied. I) the specific 3 K-sites periodic structure of the 16 DN....

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Autor principal:	Valenzuela,Carlos Y
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Dinucleotides DNA periodicity Periodicity structure Selective interactions Theories of evolution
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100018
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spelling	oai:scielo:S0716-976020140001000182015-10-30The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNAValenzuela,Carlos Y Dinucleotides DNA periodicity Periodicity structure Selective interactions Theories of evolution BACKGROUND: We found a strong selective 3-sites periodicity of deviations from randomness of the dinucleotide (DN) distribution, where both bases of DN were separated by 1, 2, K sites in prokaryotes and mtDNA. Three main aspects are studied. I) the specific 3 K-sites periodic structure of the 16 DN. II) to discard the possibility that the periodicity was produced by the highly nonrandom interactive association of contiguous bases, by studying the interaction of non-contiguous bases, the first one chosen each I sites and the second chosen J sites downstream. III) the difference between this selective periodicity of association (distance to randomness) of the four bases with the described fixed periodicities of base sequences. RESULTS: I) The 16 pairs presented a consistent periodicity in the strength of association of both bases of the pairs; the most deviated pairs are those where G and C are involved and the least deviated ones are those where A and T are involved. II) we found significant non-random interactions when the first nucleotide is chosen every I sites and the second J sites downstream until I = J = 76. III) we showed conclusive differences between these internucleotide association periodicities and sequence periodicities. CONCLUSIONS: This relational selective periodicity is different from sequence periodicities and indicates that any base strongly interacts with the bases of the residual genome; this interaction and periodicity is highly structured and systematic for every pair of bases. This interaction should be destroyed in few generations by recurrent mutation; it is only compatible with the Synthetic Theory of Evolution and agrees with the Wright's adaptive landscape conception and evolution by shifting balanced adaptive peaks.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100018en10.1186/0717-6287-47-18
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Dinucleotides DNA periodicity Periodicity structure Selective interactions Theories of evolution
spellingShingle	Dinucleotides DNA periodicity Periodicity structure Selective interactions Theories of evolution Valenzuela,Carlos Y The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
description	BACKGROUND: We found a strong selective 3-sites periodicity of deviations from randomness of the dinucleotide (DN) distribution, where both bases of DN were separated by 1, 2, K sites in prokaryotes and mtDNA. Three main aspects are studied. I) the specific 3 K-sites periodic structure of the 16 DN. II) to discard the possibility that the periodicity was produced by the highly nonrandom interactive association of contiguous bases, by studying the interaction of non-contiguous bases, the first one chosen each I sites and the second chosen J sites downstream. III) the difference between this selective periodicity of association (distance to randomness) of the four bases with the described fixed periodicities of base sequences. RESULTS: I) The 16 pairs presented a consistent periodicity in the strength of association of both bases of the pairs; the most deviated pairs are those where G and C are involved and the least deviated ones are those where A and T are involved. II) we found significant non-random interactions when the first nucleotide is chosen every I sites and the second J sites downstream until I = J = 76. III) we showed conclusive differences between these internucleotide association periodicities and sequence periodicities. CONCLUSIONS: This relational selective periodicity is different from sequence periodicities and indicates that any base strongly interacts with the bases of the residual genome; this interaction and periodicity is highly structured and systematic for every pair of bases. This interaction should be destroyed in few generations by recurrent mutation; it is only compatible with the Synthetic Theory of Evolution and agrees with the Wright's adaptive landscape conception and evolution by shifting balanced adaptive peaks.
author	Valenzuela,Carlos Y
author_facet	Valenzuela,Carlos Y
author_sort	Valenzuela,Carlos Y
title	The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
title_short	The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
title_full	The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
title_fullStr	The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
title_full_unstemmed	The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA
title_sort	structure of selective dinucleotide interactions and periodicities in d melanogaster mtdna
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100018
work_keys_str_mv	AT valenzuelacarlosy thestructureofselectivedinucleotideinteractionsandperiodicitiesindmelanogastermtdna AT valenzuelacarlosy structureofselectivedinucleotideinteractionsandperiodicitiesindmelanogastermtdna
_version_	1718441513887727616

The structure of selective dinucleotide interactions and periodicities in D melanogaster mtDNA

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