Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy

BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant t...

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Autores principales:	Rosas,Carlos, Sinning,Mariana, Ferreira,Arturo, Fuenzalida,Marcela, Lemus,David
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Angiogenesis Celecoxib Tumor
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027
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spelling	oai:scielo:S0716-976020140001000272015-10-30Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapyRosas,CarlosSinning,MarianaFerreira,ArturoFuenzalida,MarcelaLemus,David Angiogenesis Celecoxib Tumor BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to chemotherapeutical drugs used in cancer have not been described. Herein we evaluate the angiogenic and antitumor effects of Cx in the development of a drug-resistant mammary adenocarcinoma tumor (TA3-MTXR). RESULTS: Cx reduces angiogenesis in the chick embryonic chorioallantoic membrane assay (CAM), inhibits the growth and microvascular density of the murine TA3-MTXR tumor, reduces microvascular density of tumor metastases, promotes apoptosis and reduces vascular endothelial growth factor (VEGF) production and cell proliferation in the tumor. CONCLUSION: The antiangiogenic and antitumor Cx effects correlate with its activity on other tumor cell lines, suggesting that Prostaglandins (PGs) and VEGF production are involved. These results open the possibility of using Celecoxib combined with other experimental therapies, ideally aiming to get synergic effects.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027en10.1186/0717-6287-47-27
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Angiogenesis Celecoxib Tumor
spellingShingle	Angiogenesis Celecoxib Tumor Rosas,Carlos Sinning,Mariana Ferreira,Arturo Fuenzalida,Marcela Lemus,David Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
description	BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to chemotherapeutical drugs used in cancer have not been described. Herein we evaluate the angiogenic and antitumor effects of Cx in the development of a drug-resistant mammary adenocarcinoma tumor (TA3-MTXR). RESULTS: Cx reduces angiogenesis in the chick embryonic chorioallantoic membrane assay (CAM), inhibits the growth and microvascular density of the murine TA3-MTXR tumor, reduces microvascular density of tumor metastases, promotes apoptosis and reduces vascular endothelial growth factor (VEGF) production and cell proliferation in the tumor. CONCLUSION: The antiangiogenic and antitumor Cx effects correlate with its activity on other tumor cell lines, suggesting that Prostaglandins (PGs) and VEGF production are involved. These results open the possibility of using Celecoxib combined with other experimental therapies, ideally aiming to get synergic effects.
author	Rosas,Carlos Sinning,Mariana Ferreira,Arturo Fuenzalida,Marcela Lemus,David
author_facet	Rosas,Carlos Sinning,Mariana Ferreira,Arturo Fuenzalida,Marcela Lemus,David
author_sort	Rosas,Carlos
title	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
title_short	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
title_full	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
title_fullStr	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
title_full_unstemmed	Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
title_sort	celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027
work_keys_str_mv	AT rosascarlos celecoxibdecreasesgrowthandangiogenesisandpromotesapoptosisinatumorcelllineresistanttochemotherapy AT sinningmariana celecoxibdecreasesgrowthandangiogenesisandpromotesapoptosisinatumorcelllineresistanttochemotherapy AT ferreiraarturo celecoxibdecreasesgrowthandangiogenesisandpromotesapoptosisinatumorcelllineresistanttochemotherapy AT fuenzalidamarcela celecoxibdecreasesgrowthandangiogenesisandpromotesapoptosisinatumorcelllineresistanttochemotherapy AT lemusdavid celecoxibdecreasesgrowthandangiogenesisandpromotesapoptosisinatumorcelllineresistanttochemotherapy
_version_	1718441516016336896

Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy

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