Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root

BACKGROUND: This study was subjected to investigate different pharmacological properties of ethanol extract ofSolena amplexicaulis root. RESULTS: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging a...

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Autores principales:	Kabir,Md Golam, Rahman,Md Monsor, Ahmed,Nazim Uddin, Fakruddin,Md, Islam,Saiful, Mazumdar,Reaz Mohammad
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Solena amplexicaulis Antioxidant Antimicrobial Acute toxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100036
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spelling	oai:scielo:S0716-976020140001000362015-10-30Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis rootKabir,Md GolamRahman,Md MonsorAhmed,Nazim UddinFakruddin,MdIslam,SaifulMazumdar,Reaz Mohammad Solena amplexicaulis Antioxidant Antimicrobial Acute toxicity BACKGROUND: This study was subjected to investigate different pharmacological properties of ethanol extract ofSolena amplexicaulis root. RESULTS: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 µg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500 - 3000 µg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed. CONCLUSION: Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100036en10.1186/0717-6287-47-36
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Solena amplexicaulis Antioxidant Antimicrobial Acute toxicity
spellingShingle	Solena amplexicaulis Antioxidant Antimicrobial Acute toxicity Kabir,Md Golam Rahman,Md Monsor Ahmed,Nazim Uddin Fakruddin,Md Islam,Saiful Mazumdar,Reaz Mohammad Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
description	BACKGROUND: This study was subjected to investigate different pharmacological properties of ethanol extract ofSolena amplexicaulis root. RESULTS: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 µg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500 - 3000 µg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed. CONCLUSION: Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.
author	Kabir,Md Golam Rahman,Md Monsor Ahmed,Nazim Uddin Fakruddin,Md Islam,Saiful Mazumdar,Reaz Mohammad
author_facet	Kabir,Md Golam Rahman,Md Monsor Ahmed,Nazim Uddin Fakruddin,Md Islam,Saiful Mazumdar,Reaz Mohammad
author_sort	Kabir,Md Golam
title	Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
title_short	Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
title_full	Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
title_fullStr	Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
title_full_unstemmed	Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
title_sort	antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of solena amplexicaulis root
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100036
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Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root

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