CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines...

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Autores principales:	García-Labastida,Laura, Garza-Guajardo,Raquel, Barboza-Quintana,Oralia, Rodríguez-Sanchez,Irám Pablo, Ancer-Rodríguez,Jesús, Flores-Gutierrez,Juan Pablo, Gómez-Macías,Gabriela Sofía
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Breast mucinous carcinoma Inmunohistochemical Intestinal differentiation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100043
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id	oai:scielo:S0716-97602014000100043
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spelling	oai:scielo:S0716-976020140001000432015-10-30CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breastGarcía-Labastida,LauraGarza-Guajardo,RaquelBarboza-Quintana,OraliaRodríguez-Sanchez,Irám PabloAncer-Rodríguez,JesúsFlores-Gutierrez,Juan PabloGómez-Macías,Gabriela Sofía Breast mucinous carcinoma Inmunohistochemical Intestinal differentiation BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100043en10.1186/0717-6287-47-43
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Breast mucinous carcinoma Inmunohistochemical Intestinal differentiation
spellingShingle	Breast mucinous carcinoma Inmunohistochemical Intestinal differentiation García-Labastida,Laura Garza-Guajardo,Raquel Barboza-Quintana,Oralia Rodríguez-Sanchez,Irám Pablo Ancer-Rodríguez,Jesús Flores-Gutierrez,Juan Pablo Gómez-Macías,Gabriela Sofía CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
description	BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
author	García-Labastida,Laura Garza-Guajardo,Raquel Barboza-Quintana,Oralia Rodríguez-Sanchez,Irám Pablo Ancer-Rodríguez,Jesús Flores-Gutierrez,Juan Pablo Gómez-Macías,Gabriela Sofía
author_facet	García-Labastida,Laura Garza-Guajardo,Raquel Barboza-Quintana,Oralia Rodríguez-Sanchez,Irám Pablo Ancer-Rodríguez,Jesús Flores-Gutierrez,Juan Pablo Gómez-Macías,Gabriela Sofía
author_sort	García-Labastida,Laura
title	CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
title_short	CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
title_full	CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
title_fullStr	CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
title_full_unstemmed	CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
title_sort	cdx-2, muc-2 and b-catenin as intestinal markers in pure mucinous carcinoma of the breast
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100043
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CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

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