Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population
BACKGROUND: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been...
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Sociedad de Biología de Chile
2014
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oai:scielo:S0716-976020140001000562015-10-30Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean populationAdonis,Marta IDíaz,JoseMiranda,Veronica RChahuan,MarcoZambrano,AlcidesBenitez,Hugo CCampos,MonicaAvaria,PabloUrzúa,UlisesMarín,PedroGohurdett,MarielaCisterna,YasnaGil,Lionel Early detection Biomarkers Lung cancer BACKGROUND: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 μg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL). RESULTS: Half of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%). CONCLUSION: This work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100056en10.1186/0717-6287-47-62 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Early detection Biomarkers Lung cancer |
| spellingShingle |
Early detection Biomarkers Lung cancer Adonis,Marta I Díaz,Jose Miranda,Veronica R Chahuan,Marco Zambrano,Alcides Benitez,Hugo C Campos,Monica Avaria,Pablo Urzúa,Ulises Marín,Pedro Gohurdett,Mariela Cisterna,Yasna Gil,Lionel Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| description |
BACKGROUND: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 μg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL). RESULTS: Half of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%). CONCLUSION: This work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile. |
| author |
Adonis,Marta I Díaz,Jose Miranda,Veronica R Chahuan,Marco Zambrano,Alcides Benitez,Hugo C Campos,Monica Avaria,Pablo Urzúa,Ulises Marín,Pedro Gohurdett,Mariela Cisterna,Yasna Gil,Lionel |
| author_facet |
Adonis,Marta I Díaz,Jose Miranda,Veronica R Chahuan,Marco Zambrano,Alcides Benitez,Hugo C Campos,Monica Avaria,Pablo Urzúa,Ulises Marín,Pedro Gohurdett,Mariela Cisterna,Yasna Gil,Lionel |
| author_sort |
Adonis,Marta I |
| title |
Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| title_short |
Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| title_full |
Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| title_fullStr |
Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| title_full_unstemmed |
Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population |
| title_sort |
biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk chilean population |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2014 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100056 |
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