Cancer stem cells - the current status of an old concept: literature review and clinical approaches

As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being...

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Autores principales:	Fulawka,Lukasz, Donizy,Piotr, Halon,Agnieszka
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Cancer stem cells Stem cells Tumour-initiating cells Tumour-propagating cells Carcinogenesis Tumour heterogeneity Clonal evolution
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100060
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spelling	oai:scielo:S0716-976020140001000602015-10-30Cancer stem cells - the current status of an old concept: literature review and clinical approachesFulawka,LukaszDonizy,PiotrHalon,Agnieszka Cancer stem cells Stem cells Tumour-initiating cells Tumour-propagating cells Carcinogenesis Tumour heterogeneity Clonal evolution As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being able to self-renew and produce a heterogeneous tumour cell population are cancer stem cells. CSCs probably derive from normal stem cells, although progenitor cells may be taken into consideration as the source of cancer stem cells. CSCs reside in the niche defined as the microenvironment formed by stromal cells, vasculature and extracellular matrix. The CSC assays include FACS sorting, xenotransplantation to immunodeficient mice (SCID), incubation with Hoechst 33342 dye, cell culture in non-adherent conditions, cell culture with bromodeoxyuridine. CSCs have certain properties that make them resistant to anticancer therapy, which suggests they may be the target for potential therapeutic strategies.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100060en10.1186/0717-6287-47-66
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cancer stem cells Stem cells Tumour-initiating cells Tumour-propagating cells Carcinogenesis Tumour heterogeneity Clonal evolution
spellingShingle	Cancer stem cells Stem cells Tumour-initiating cells Tumour-propagating cells Carcinogenesis Tumour heterogeneity Clonal evolution Fulawka,Lukasz Donizy,Piotr Halon,Agnieszka Cancer stem cells - the current status of an old concept: literature review and clinical approaches
description	As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being able to self-renew and produce a heterogeneous tumour cell population are cancer stem cells. CSCs probably derive from normal stem cells, although progenitor cells may be taken into consideration as the source of cancer stem cells. CSCs reside in the niche defined as the microenvironment formed by stromal cells, vasculature and extracellular matrix. The CSC assays include FACS sorting, xenotransplantation to immunodeficient mice (SCID), incubation with Hoechst 33342 dye, cell culture in non-adherent conditions, cell culture with bromodeoxyuridine. CSCs have certain properties that make them resistant to anticancer therapy, which suggests they may be the target for potential therapeutic strategies.
author	Fulawka,Lukasz Donizy,Piotr Halon,Agnieszka
author_facet	Fulawka,Lukasz Donizy,Piotr Halon,Agnieszka
author_sort	Fulawka,Lukasz
title	Cancer stem cells - the current status of an old concept: literature review and clinical approaches
title_short	Cancer stem cells - the current status of an old concept: literature review and clinical approaches
title_full	Cancer stem cells - the current status of an old concept: literature review and clinical approaches
title_fullStr	Cancer stem cells - the current status of an old concept: literature review and clinical approaches
title_full_unstemmed	Cancer stem cells - the current status of an old concept: literature review and clinical approaches
title_sort	cancer stem cells - the current status of an old concept: literature review and clinical approaches
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100060
work_keys_str_mv	AT fulawkalukasz cancerstemcellsthecurrentstatusofanoldconceptliteraturereviewandclinicalapproaches AT donizypiotr cancerstemcellsthecurrentstatusofanoldconceptliteraturereviewandclinicalapproaches AT halonagnieszka cancerstemcellsthecurrentstatusofanoldconceptliteraturereviewandclinicalapproaches
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Cancer stem cells - the current status of an old concept: literature review and clinical approaches

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