Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers

BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matias,Carlos M, Dionísio,Jose C, Saggau,Peter, Quinta-Ferreira,Maria Emilia
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Zinc Neurotransmission Glutamatergic Co-release Metabotropic fluorescence Inhibition
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100067
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602014000100067
record_format	dspace
spelling	oai:scielo:S0716-976020140001000672015-10-30Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibersMatias,Carlos MDionísio,Jose CSaggau,PeterQuinta-Ferreira,Maria Emilia Zinc Neurotransmission Glutamatergic Co-release Metabotropic fluorescence Inhibition BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals. RESULTS: Studies were performed using the membrane-permeant fluorescent zinc probe TSQ, and indicate that DCG-IV almost completely abolishes mossy fiber zinc changes as it does with synaptic transmission. CONCLUSIONS: Zinc signaling is regulated by the activation of type II metabotropic receptors, as it has been previously shown for glutamate, further supporting the corelease of glutamate and zinc from mossy fibers.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100067en10.1186/0717-6287-47-73
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Zinc Neurotransmission Glutamatergic Co-release Metabotropic fluorescence Inhibition
spellingShingle	Zinc Neurotransmission Glutamatergic Co-release Metabotropic fluorescence Inhibition Matias,Carlos M Dionísio,Jose C Saggau,Peter Quinta-Ferreira,Maria Emilia Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
description	BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals. RESULTS: Studies were performed using the membrane-permeant fluorescent zinc probe TSQ, and indicate that DCG-IV almost completely abolishes mossy fiber zinc changes as it does with synaptic transmission. CONCLUSIONS: Zinc signaling is regulated by the activation of type II metabotropic receptors, as it has been previously shown for glutamate, further supporting the corelease of glutamate and zinc from mossy fibers.
author	Matias,Carlos M Dionísio,Jose C Saggau,Peter Quinta-Ferreira,Maria Emilia
author_facet	Matias,Carlos M Dionísio,Jose C Saggau,Peter Quinta-Ferreira,Maria Emilia
author_sort	Matias,Carlos M
title	Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
title_short	Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
title_full	Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
title_fullStr	Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
title_full_unstemmed	Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
title_sort	activation of group ii metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100067
work_keys_str_mv	AT matiascarlosm activationofgroupiimetabotropicglutamatereceptorsblockszincreleasefromhippocampalmossyfibers AT dionisiojosec activationofgroupiimetabotropicglutamatereceptorsblockszincreleasefromhippocampalmossyfibers AT saggaupeter activationofgroupiimetabotropicglutamatereceptorsblockszincreleasefromhippocampalmossyfibers AT quintaferreiramariaemilia activationofgroupiimetabotropicglutamatereceptorsblockszincreleasefromhippocampalmossyfibers
_version_	1718441526066937856

Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers

Ejemplares similares