Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice

BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochond...

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Autores principales:	Soto-Urquieta,María G, López-Briones,Sergio, Pérez-Vázquez,Victoriano, Saavedra-Molina,Alfredo, González-Hernández,Gloria A, Ramírez-Emiliano,Joel
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Diabetes Mitochondria Curcumin ATPase activity Nitric oxide synthesis Lipid oxidation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100068
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spelling	oai:scielo:S0716-976020140001000682015-10-30Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db miceSoto-Urquieta,María GLópez-Briones,SergioPérez-Vázquez,VictorianoSaavedra-Molina,AlfredoGonzález-Hernández,Gloria ARamírez-Emiliano,Joel Diabetes Mitochondria Curcumin ATPase activity Nitric oxide synthesis Lipid oxidation BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice. RESULTS: Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice. CONCLUSIONS: These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100068en10.1186/0717-6287-47-74
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes Mitochondria Curcumin ATPase activity Nitric oxide synthesis Lipid oxidation
spellingShingle	Diabetes Mitochondria Curcumin ATPase activity Nitric oxide synthesis Lipid oxidation Soto-Urquieta,María G López-Briones,Sergio Pérez-Vázquez,Victoriano Saavedra-Molina,Alfredo González-Hernández,Gloria A Ramírez-Emiliano,Joel Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
description	BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice. RESULTS: Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice. CONCLUSIONS: These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.
author	Soto-Urquieta,María G López-Briones,Sergio Pérez-Vázquez,Victoriano Saavedra-Molina,Alfredo González-Hernández,Gloria A Ramírez-Emiliano,Joel
author_facet	Soto-Urquieta,María G López-Briones,Sergio Pérez-Vázquez,Victoriano Saavedra-Molina,Alfredo González-Hernández,Gloria A Ramírez-Emiliano,Joel
author_sort	Soto-Urquieta,María G
title	Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
title_short	Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
title_full	Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
title_fullStr	Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
title_full_unstemmed	Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
title_sort	curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100068
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Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice

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