Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats

BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this st...

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Autores principales:	Moreira,Priscila R, Maioli,Marcos A, Medeiros,Hyllana CD, Guelfi,Marieli, Pereira,Flávia TV, Mingatto,Fábio E
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2014
Materias:	Bixin Carbon tetrachloride Hepatotoxicity Oxidative stress Protective activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100072
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spelling	oai:scielo:S0716-976020140001000722015-10-30Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in ratsMoreira,Priscila RMaioli,Marcos AMedeiros,Hyllana CDGuelfi,MarieliPereira,Flávia TVMingatto,Fábio E Bixin Carbon tetrachloride Hepatotoxicity Oxidative stress Protective activity BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats. RESULTS: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg-1 body wt.) was injected intraperitoneally, and bixin (5.0 mg kg-1 body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment. CONCLUSION: Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.47 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100072en10.1186/0717-6287-47-49
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bixin Carbon tetrachloride Hepatotoxicity Oxidative stress Protective activity
spellingShingle	Bixin Carbon tetrachloride Hepatotoxicity Oxidative stress Protective activity Moreira,Priscila R Maioli,Marcos A Medeiros,Hyllana CD Guelfi,Marieli Pereira,Flávia TV Mingatto,Fábio E Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
description	BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats. RESULTS: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg-1 body wt.) was injected intraperitoneally, and bixin (5.0 mg kg-1 body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment. CONCLUSION: Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound.
author	Moreira,Priscila R Maioli,Marcos A Medeiros,Hyllana CD Guelfi,Marieli Pereira,Flávia TV Mingatto,Fábio E
author_facet	Moreira,Priscila R Maioli,Marcos A Medeiros,Hyllana CD Guelfi,Marieli Pereira,Flávia TV Mingatto,Fábio E
author_sort	Moreira,Priscila R
title	Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
title_short	Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
title_full	Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
title_fullStr	Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
title_full_unstemmed	Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
title_sort	protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
publisher	Sociedad de Biología de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100072
work_keys_str_mv	AT moreirapriscilar protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats AT maiolimarcosa protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats AT medeiroshyllanacd protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats AT guelfimarieli protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats AT pereiraflaviatv protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats AT mingattofabioe protectiveeffectofbixinoncarbontetrachlorideinducedhepatotoxicityinrats
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Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats

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