Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells
BACKGROUND: Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives ofZingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human i...
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Sociedad de Biología de Chile
2015
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oai:scielo:S0716-976020150001000012016-02-16Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cellsDanciu,CorinaVlaia,LaviniaFetea,FlorinelaHancianu,MonicaCoricovac,Dorina ECiurlea,Sorina AM Şoica,CodruţaMarincu,IosifVlaia,VicentiuDehelean,Cristina ATrandafirescu,Cristina Curcuma longa Linnaeus Zingiber officinale Roscoe Polyphenols Antioxidant Melanoma BACKGROUND: Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives ofZingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human immunodeficiency virus properties and anticancer effects. This study was aimed to analyse the ethanolic extracts of Curcuma rhizome (Curcuma longa Linnaeus) and Zingiber rhizome (Zingiber officinale Roscoe) in terms of polyphenols, antioxidant activity and anti-melanoma potential employing the B164A5 murine melanoma cell line. RESULTS: In order to evaluate the total content of polyphenols we used Folin-Ciocâlteu method. The antioxidant activity of the two ethanolic extracts was determined by DPPH assay, and for the control of antiproliferative effect it was used MTT proliferation assay, DAPI staining and Annexin-FITC-7AAD double staining test. Results showed increased polyphenols amount and antioxidant activity forCurcuma rhizome ethanolic extract. Moreover, 100 μg/ml of ethanolic plant extract from both vegetal products presented in a different manner an antiproliferative, respectively a proapoptotic effect on the selected cell line. CONCLUSIONS: The study concludes that Curcuma rhizome may be a promising natural source for active compounds against malignant melanoma.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100001en10.1186/0717-6287-48-1 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Curcuma longa Linnaeus Zingiber officinale Roscoe Polyphenols Antioxidant Melanoma |
| spellingShingle |
Curcuma longa Linnaeus Zingiber officinale Roscoe Polyphenols Antioxidant Melanoma Danciu,Corina Vlaia,Lavinia Fetea,Florinela Hancianu,Monica Coricovac,Dorina E Ciurlea,Sorina A M Şoica,Codruţa Marincu,Iosif Vlaia,Vicentiu Dehelean,Cristina A Trandafirescu,Cristina Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| description |
BACKGROUND: Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives ofZingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human immunodeficiency virus properties and anticancer effects. This study was aimed to analyse the ethanolic extracts of Curcuma rhizome (Curcuma longa Linnaeus) and Zingiber rhizome (Zingiber officinale Roscoe) in terms of polyphenols, antioxidant activity and anti-melanoma potential employing the B164A5 murine melanoma cell line. RESULTS: In order to evaluate the total content of polyphenols we used Folin-Ciocâlteu method. The antioxidant activity of the two ethanolic extracts was determined by DPPH assay, and for the control of antiproliferative effect it was used MTT proliferation assay, DAPI staining and Annexin-FITC-7AAD double staining test. Results showed increased polyphenols amount and antioxidant activity forCurcuma rhizome ethanolic extract. Moreover, 100 μg/ml of ethanolic plant extract from both vegetal products presented in a different manner an antiproliferative, respectively a proapoptotic effect on the selected cell line. CONCLUSIONS: The study concludes that Curcuma rhizome may be a promising natural source for active compounds against malignant melanoma. |
| author |
Danciu,Corina Vlaia,Lavinia Fetea,Florinela Hancianu,Monica Coricovac,Dorina E Ciurlea,Sorina A M Şoica,Codruţa Marincu,Iosif Vlaia,Vicentiu Dehelean,Cristina A Trandafirescu,Cristina |
| author_facet |
Danciu,Corina Vlaia,Lavinia Fetea,Florinela Hancianu,Monica Coricovac,Dorina E Ciurlea,Sorina A M Şoica,Codruţa Marincu,Iosif Vlaia,Vicentiu Dehelean,Cristina A Trandafirescu,Cristina |
| author_sort |
Danciu,Corina |
| title |
Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| title_short |
Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| title_full |
Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| title_fullStr |
Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| title_full_unstemmed |
Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells |
| title_sort |
evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of zingiberaceae family against b164a5 murine melanoma cells |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100001 |
| work_keys_str_mv |
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| _version_ |
1718441528295161856 |