Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats

BACKGROUND: Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the hepato-protective effect of rutin on CCl4-induced hepatotoxicity in rats. R...

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Autores principales: Hafez,Mohamed M, Al-Harbi,Naif O, Al-Hoshani,Ali Rashed, Al-hosaini,Khaled A, Al Shrari,Shakir D, Al Rejaie,Salim S, Sayed-Ahmed,Mohamed M, Al-Shabanah,Othman A
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2015
Materias:
Hepatotoxicity
Rutin
Inflammatory cytokine
MEK5
FADD
STAT3
JAK genes expression
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100030
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