Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

BACKGROUND: Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore t...

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Autores principales:	Chalghoum,Abdelkader, Noichri,Yosri, Karkouch,Ines, Dandana,Azza, Baudin,Bruno, Jeridi,Guieder, Ferchichi,Salima, Miled,Abdelhédi
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2015
Materias:	Acute coronary syndrome Endothelin-1 Hyperhomocysteinemia Risk factors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100032
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spelling	oai:scielo:S0716-976020150001000322016-02-16Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseasesChalghoum,AbdelkaderNoichri,YosriKarkouch,InesDandana,AzzaBaudin,BrunoJeridi,GuiederFerchichi,SalimaMiled,Abdelhédi Acute coronary syndrome Endothelin-1 Hyperhomocysteinemia Risk factors BACKGROUND: Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore the variation of two coronary risk parameters not mentioned by Framingham cohorts, hyperhomocysteinemia and endothelin-1 (ET-1) in Tunisian coronary and the study of the variation of these parameters based on various cardiac risk factors and metabolic relationship between them.To 157 coronary and 142 healthy subjects, the concentration of homocysteine was quantified by fluorescence polarization immunoassay; the concentration of ET-1 was measured by an analytical technique, the High Performance Liquid Chromatography (HPLC) coupled with mass spectrometry. RESULTS: Our study showed that homocysteine and ET-1 were significantly higher in patients compared to healthy subjects (24.40 ± 12.5 μmol/L vs 7.44 ± 2.5 μmol/L p <0.00001) for homocysteine and (15.2 ± 5.3 nmol/L vs 7.1 ± 2.7 nmol/L, p <0.00001) for ET-1. On the other hand, homocysteine varies according to tobacco and diabetes while ET-1 depends on the sex, hypertension, smoking, obesity and dyslipidemia and a statistically negative correlation was shown between homocysteine and ET-1 in coronary patients (r = -0.66 p <0.00001. CONCLUSION: The study of the variation of these two parameters in coronary patients and metabolic exploration of the relationship between homocysteine and ET-1 according to various risk factors and the interactions between themselves facilitates the decision of therapeutic treatment.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100032en10.1186/S40659-015-0018-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Acute coronary syndrome Endothelin-1 Hyperhomocysteinemia Risk factors
spellingShingle	Acute coronary syndrome Endothelin-1 Hyperhomocysteinemia Risk factors Chalghoum,Abdelkader Noichri,Yosri Karkouch,Ines Dandana,Azza Baudin,Bruno Jeridi,Guieder Ferchichi,Salima Miled,Abdelhédi Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
description	BACKGROUND: Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore the variation of two coronary risk parameters not mentioned by Framingham cohorts, hyperhomocysteinemia and endothelin-1 (ET-1) in Tunisian coronary and the study of the variation of these parameters based on various cardiac risk factors and metabolic relationship between them.To 157 coronary and 142 healthy subjects, the concentration of homocysteine was quantified by fluorescence polarization immunoassay; the concentration of ET-1 was measured by an analytical technique, the High Performance Liquid Chromatography (HPLC) coupled with mass spectrometry. RESULTS: Our study showed that homocysteine and ET-1 were significantly higher in patients compared to healthy subjects (24.40 ± 12.5 μmol/L vs 7.44 ± 2.5 μmol/L p <0.00001) for homocysteine and (15.2 ± 5.3 nmol/L vs 7.1 ± 2.7 nmol/L, p <0.00001) for ET-1. On the other hand, homocysteine varies according to tobacco and diabetes while ET-1 depends on the sex, hypertension, smoking, obesity and dyslipidemia and a statistically negative correlation was shown between homocysteine and ET-1 in coronary patients (r = -0.66 p <0.00001. CONCLUSION: The study of the variation of these two parameters in coronary patients and metabolic exploration of the relationship between homocysteine and ET-1 according to various risk factors and the interactions between themselves facilitates the decision of therapeutic treatment.
author	Chalghoum,Abdelkader Noichri,Yosri Karkouch,Ines Dandana,Azza Baudin,Bruno Jeridi,Guieder Ferchichi,Salima Miled,Abdelhédi
author_facet	Chalghoum,Abdelkader Noichri,Yosri Karkouch,Ines Dandana,Azza Baudin,Bruno Jeridi,Guieder Ferchichi,Salima Miled,Abdelhédi
author_sort	Chalghoum,Abdelkader
title	Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
title_short	Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
title_full	Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
title_fullStr	Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
title_full_unstemmed	Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases
title_sort	metabolic interactions between hyperhomocysteinemia and endothelin-1 among tunisian patients with acute coronary diseases
publisher	Sociedad de Biología de Chile
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100032
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Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

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