Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B

BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA...

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Autores principales:	Cai,Guilan, Qiao,Shanshan, Chen,Kui
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2015
Materias:	miR-221 Glioma SEMA3B Cancer metastasis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100037
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spelling	oai:scielo:S0716-976020150001000372016-02-16Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3BCai,GuilanQiao,ShanshanChen,Kui miR-221 Glioma SEMA3B Cancer metastasis BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. CONCLUSION: Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100037en10.1186/S40659-015-0030-Y
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	miR-221 Glioma SEMA3B Cancer metastasis
spellingShingle	miR-221 Glioma SEMA3B Cancer metastasis Cai,Guilan Qiao,Shanshan Chen,Kui Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
description	BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. CONCLUSION: Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.
author	Cai,Guilan Qiao,Shanshan Chen,Kui
author_facet	Cai,Guilan Qiao,Shanshan Chen,Kui
author_sort	Cai,Guilan
title	Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
title_short	Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
title_full	Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
title_fullStr	Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
title_full_unstemmed	Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B
title_sort	suppression of mir-221 inhibits glioma cells proliferation and invasion via targeting sema3b
publisher	Sociedad de Biología de Chile
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100037
work_keys_str_mv	AT caiguilan suppressionofmir221inhibitsgliomacellsproliferationandinvasionviatargetingsema3b AT qiaoshanshan suppressionofmir221inhibitsgliomacellsproliferationandinvasionviatargetingsema3b AT chenkui suppressionofmir221inhibitsgliomacellsproliferationandinvasionviatargetingsema3b
_version_	1718441536696352768

Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B

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