CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations

BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplanta...

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Autores principales:	Takahashi,Hiroshi, Ikeda,Kazuhiko, Ogawa,Kazuei, Saito,Syunnichi, Ngoma,Alain M, Mashimo,Yumiko, Ueda,Koki, Furukawa,Miki, Shichishima-Nakamura,Akiko, Ohkawara,Hiroshi, Nollet,Kenneth E, Ohto,Hitoshi, Takeishi,Yasuchika
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2015
Materias:	Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041
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spelling	oai:scielo:S0716-976020150001000412016-02-16CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantationsTakahashi,HiroshiIkeda,KazuhikoOgawa,KazueiSaito,SyunnichiNgoma,Alain MMashimo,YumikoUeda,KokiFurukawa,MikiShichishima-Nakamura,AkikoOhkawara,HiroshiNollet,Kenneth EOhto,HitoshiTakeishi,Yasuchika Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041en10.1186/S40659-015-0033-8
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease
spellingShingle	Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease Takahashi,Hiroshi Ikeda,Kazuhiko Ogawa,Kazuei Saito,Syunnichi Ngoma,Alain M Mashimo,Yumiko Ueda,Koki Furukawa,Miki Shichishima-Nakamura,Akiko Ohkawara,Hiroshi Nollet,Kenneth E Ohto,Hitoshi Takeishi,Yasuchika CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
description	BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
author	Takahashi,Hiroshi Ikeda,Kazuhiko Ogawa,Kazuei Saito,Syunnichi Ngoma,Alain M Mashimo,Yumiko Ueda,Koki Furukawa,Miki Shichishima-Nakamura,Akiko Ohkawara,Hiroshi Nollet,Kenneth E Ohto,Hitoshi Takeishi,Yasuchika
author_facet	Takahashi,Hiroshi Ikeda,Kazuhiko Ogawa,Kazuei Saito,Syunnichi Ngoma,Alain M Mashimo,Yumiko Ueda,Koki Furukawa,Miki Shichishima-Nakamura,Akiko Ohkawara,Hiroshi Nollet,Kenneth E Ohto,Hitoshi Takeishi,Yasuchika
author_sort	Takahashi,Hiroshi
title	CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
title_short	CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
title_full	CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
title_fullStr	CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
title_full_unstemmed	CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
title_sort	cd4+ t cells in aged or thymectomized recipients of allogeneic stem cell transplantations
publisher	Sociedad de Biología de Chile
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041
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CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations

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