Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet

BACKGROUND: Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and d...

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Autores principales:	Hernández-Salinas,Romina, Decap,Valerie, Leguina,Alberto, Cáceres,Patricio, Perez,Druso, Urquiaga,Ines, Iturriaga,Rodrigo, Velarde,Victoria
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2015
Materias:	Insulin resistance Oxidative stress Metabolic syndrome Wine grape powder
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100053
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spelling	oai:scielo:S0716-976020150001000532016-02-16Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose dietHernández-Salinas,RominaDecap,ValerieLeguina,AlbertoCáceres,PatricioPerez,DrusoUrquiaga,InesIturriaga,RodrigoVelarde,Victoria Insulin resistance Oxidative stress Metabolic syndrome Wine grape powder BACKGROUND: Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. METHODS: Male Sprague-Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thio-barbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. RESULTS: Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. CONCLUSIONS: Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100053en10.1186/s40659-015-0045-4
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Insulin resistance Oxidative stress Metabolic syndrome Wine grape powder
spellingShingle	Insulin resistance Oxidative stress Metabolic syndrome Wine grape powder Hernández-Salinas,Romina Decap,Valerie Leguina,Alberto Cáceres,Patricio Perez,Druso Urquiaga,Ines Iturriaga,Rodrigo Velarde,Victoria Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
description	BACKGROUND: Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. METHODS: Male Sprague-Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thio-barbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. RESULTS: Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. CONCLUSIONS: Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.
author	Hernández-Salinas,Romina Decap,Valerie Leguina,Alberto Cáceres,Patricio Perez,Druso Urquiaga,Ines Iturriaga,Rodrigo Velarde,Victoria
author_facet	Hernández-Salinas,Romina Decap,Valerie Leguina,Alberto Cáceres,Patricio Perez,Druso Urquiaga,Ines Iturriaga,Rodrigo Velarde,Victoria
author_sort	Hernández-Salinas,Romina
title	Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
title_short	Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
title_full	Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
title_fullStr	Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
title_full_unstemmed	Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
title_sort	antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
publisher	Sociedad de Biología de Chile
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100053
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Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet

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