Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produ...

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Autores principales: Koriauli,S., Natsvlishvili,N., Barbakadze,T., Mikeladze,D.
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2015
Materias:
Interleukin-10
NMDA-receptor
NR2B subunit
NADPH-oxidase
Rac1
BiP
SigR1
ER stress
Neurodegeneration
Neuroinflammation
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100055
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