A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression
BACKGROUND: Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the de...
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Sociedad de Biología de Chile
2015
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oai:scielo:S0716-976020150001000612016-02-16A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progressionJurczak,AnnaKościelniak,DorotaPapież,MonikaVyhouskaya,PalinaKrzyściak,Wirginia β-defensin-2 Histatin-5 Early childhood caries BACKGROUND: Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease METHODS: The objective of the studies was to determine the role of histatin-5 and β-defensing-2 as a diagnostic marker of early childhood caries progression. In this work, results of concentration determination of two salivary proteins (histatin-5 and β-defensin-2) were presented. In addition, bacterial profiles from dental plaque in various stages of ECC and control were marked. The assessment of alteration in the concentration of these two proteins in a study group of children with various stages of ECC and a control group consisting of children with no symptoms was performed by enzyme-linked immunosorbent assays RESULTS: The statistical analysis showed a significant increase in the concentration of histatin-5 and β-defensin-2 in the study group compared to the control group and correlated with the progression of the disease CONCLUSIONS: The confirmation of concentration changes in these proteins during the progression of dental caries may discover valuable disease progression biomarkersinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100061en10.1186/S40659-015-0050-7 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
β-defensin-2 Histatin-5 Early childhood caries |
| spellingShingle |
β-defensin-2 Histatin-5 Early childhood caries Jurczak,Anna Kościelniak,Dorota Papież,Monika Vyhouskaya,Palina Krzyściak,Wirginia A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| description |
BACKGROUND: Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease METHODS: The objective of the studies was to determine the role of histatin-5 and β-defensing-2 as a diagnostic marker of early childhood caries progression. In this work, results of concentration determination of two salivary proteins (histatin-5 and β-defensin-2) were presented. In addition, bacterial profiles from dental plaque in various stages of ECC and control were marked. The assessment of alteration in the concentration of these two proteins in a study group of children with various stages of ECC and a control group consisting of children with no symptoms was performed by enzyme-linked immunosorbent assays RESULTS: The statistical analysis showed a significant increase in the concentration of histatin-5 and β-defensin-2 in the study group compared to the control group and correlated with the progression of the disease CONCLUSIONS: The confirmation of concentration changes in these proteins during the progression of dental caries may discover valuable disease progression biomarkers |
| author |
Jurczak,Anna Kościelniak,Dorota Papież,Monika Vyhouskaya,Palina Krzyściak,Wirginia |
| author_facet |
Jurczak,Anna Kościelniak,Dorota Papież,Monika Vyhouskaya,Palina Krzyściak,Wirginia |
| author_sort |
Jurczak,Anna |
| title |
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| title_short |
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| title_full |
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| title_fullStr |
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| title_full_unstemmed |
A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| title_sort |
study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100061 |
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