In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans

The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary change in the environment where the beginning of a new organism takes place. In mammals fertilization occurs in the maternal oviduct, where there are unique conditions for guaranteeing the encounter of the game...

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Autores principales:	Ventura-Juncá,Patricio, Irarrázaval,Isabel, Rolle,Augusto J, Gutiérrez,Juan I, Moreno,Ricardo D, Santos,Manuel J
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2015
Materias:	In vitro fertilization (IVF) in mammals Epigenetics Developmental alterations Bioethical implications
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100068
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spelling	oai:scielo:S0716-976020150001000682016-02-16In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humansVentura-Juncá,PatricioIrarrázaval,IsabelRolle,Augusto JGutiérrez,Juan IMoreno,Ricardo DSantos,Manuel J In vitro fertilization (IVF) in mammals Epigenetics Developmental alterations Bioethical implications The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary change in the environment where the beginning of a new organism takes place. In mammals fertilization occurs in the maternal oviduct, where there are unique conditions for guaranteeing the encounter of the gametes and the first stages of development of the embryo and thus its future. During this period a major epigenetic reprogramming takes place that is crucial for the normal fate of the embryo. This epigenetic reprogramming is very vulnerable to changes in environmental conditions such as the ones implied in IVF, including in vitro culture, nutrition, light, temperature, oxygen tension, embryo-maternal signaling, and the general absence of protection against foreign elements that could affect the stability of this process. The objective of this review is to update the impact of the various conditions inherent in the use of IVF on the epigenetic profile and outcomes of mammalian embryos, including superovulation, IVF technique, embryo culture and manipulation and absence of embryo-maternal signaling. It also covers the possible transgenerational inheritance of the epigenetic alterations associated with assisted reproductive technologies (ART), including its phenotypic consequences as is in the case of the large offspring syndrome (LOS). Finally, the important scientific and bioethical implications of the results found in animals are discussed in terms of the ART in humans.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.48 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100068en10.1186/s40659-015-0059-y
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	In vitro fertilization (IVF) in mammals Epigenetics Developmental alterations Bioethical implications
spellingShingle	In vitro fertilization (IVF) in mammals Epigenetics Developmental alterations Bioethical implications Ventura-Juncá,Patricio Irarrázaval,Isabel Rolle,Augusto J Gutiérrez,Juan I Moreno,Ricardo D Santos,Manuel J In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
description	The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary change in the environment where the beginning of a new organism takes place. In mammals fertilization occurs in the maternal oviduct, where there are unique conditions for guaranteeing the encounter of the gametes and the first stages of development of the embryo and thus its future. During this period a major epigenetic reprogramming takes place that is crucial for the normal fate of the embryo. This epigenetic reprogramming is very vulnerable to changes in environmental conditions such as the ones implied in IVF, including in vitro culture, nutrition, light, temperature, oxygen tension, embryo-maternal signaling, and the general absence of protection against foreign elements that could affect the stability of this process. The objective of this review is to update the impact of the various conditions inherent in the use of IVF on the epigenetic profile and outcomes of mammalian embryos, including superovulation, IVF technique, embryo culture and manipulation and absence of embryo-maternal signaling. It also covers the possible transgenerational inheritance of the epigenetic alterations associated with assisted reproductive technologies (ART), including its phenotypic consequences as is in the case of the large offspring syndrome (LOS). Finally, the important scientific and bioethical implications of the results found in animals are discussed in terms of the ART in humans.
author	Ventura-Juncá,Patricio Irarrázaval,Isabel Rolle,Augusto J Gutiérrez,Juan I Moreno,Ricardo D Santos,Manuel J
author_facet	Ventura-Juncá,Patricio Irarrázaval,Isabel Rolle,Augusto J Gutiérrez,Juan I Moreno,Ricardo D Santos,Manuel J
author_sort	Ventura-Juncá,Patricio
title	In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
title_short	In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
title_full	In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
title_fullStr	In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
title_full_unstemmed	In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
title_sort	in vitro fertilization (ivf) in mammals: epigenetic and developmental alterations. scientific and bioethical implications for ivf in humans
publisher	Sociedad de Biología de Chile
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100068
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In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans

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