Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice

BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer. This study aimed to examine the effect of CpG ODN on acute radiation-induced l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li,Xuan, Xu,Guoxiong, Qiao,Tiankui, Yuan,Sujuan, Zhuang,Xibing
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	CpG ODN Acute radiation-induced lung injury Reactive oxygen species
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602016000100008
record_format	dspace
spelling	oai:scielo:S0716-976020160001000082016-12-01Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in miceLi,XuanXu,GuoxiongQiao,TiankuiYuan,SujuanZhuang,Xibing CpG ODN Acute radiation-induced lung injury Reactive oxygen species BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer. This study aimed to examine the effect of CpG ODN on acute radiation-induced lung injury in mice. METHODS AND RESULTS: The mouse model of radiation-induced lung injury was established by a single dose of 20 Gy X-rays exposure to the left lung. The results showed that the pneumonia score was lower in RT+CpG group than in RT group on 15th and 30th days. Compared with RT group, CpG ODN reduced the serum concentrations of MDA (P < 0.05) and increased the serum concentrations of SOD, GSH (P < 0.05). The serum concentration of TNF-α in RT+CpG group was lower on 15th and 30th days post-irradiation (P < 0.05). CONCLUSION: The study demonstrated that CpG ODN has preventive effects of acute radiation-induced lung injury in mice. Lung inflammatory reaction and oxidative stress are promoted in the initiation of radiation-induced pneumonia. CpG ODN may reduce the injury of reactive oxygen species and adjust the serum TNF-α concentration in the mice after irradiation, which reduces the generation of the inflammatory cytokines.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100008en10.1186/s40659-016-0068-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	CpG ODN Acute radiation-induced lung injury Reactive oxygen species
spellingShingle	CpG ODN Acute radiation-induced lung injury Reactive oxygen species Li,Xuan Xu,Guoxiong Qiao,Tiankui Yuan,Sujuan Zhuang,Xibing Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
description	BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer. This study aimed to examine the effect of CpG ODN on acute radiation-induced lung injury in mice. METHODS AND RESULTS: The mouse model of radiation-induced lung injury was established by a single dose of 20 Gy X-rays exposure to the left lung. The results showed that the pneumonia score was lower in RT+CpG group than in RT group on 15th and 30th days. Compared with RT group, CpG ODN reduced the serum concentrations of MDA (P < 0.05) and increased the serum concentrations of SOD, GSH (P < 0.05). The serum concentration of TNF-α in RT+CpG group was lower on 15th and 30th days post-irradiation (P < 0.05). CONCLUSION: The study demonstrated that CpG ODN has preventive effects of acute radiation-induced lung injury in mice. Lung inflammatory reaction and oxidative stress are promoted in the initiation of radiation-induced pneumonia. CpG ODN may reduce the injury of reactive oxygen species and adjust the serum TNF-α concentration in the mice after irradiation, which reduces the generation of the inflammatory cytokines.
author	Li,Xuan Xu,Guoxiong Qiao,Tiankui Yuan,Sujuan Zhuang,Xibing
author_facet	Li,Xuan Xu,Guoxiong Qiao,Tiankui Yuan,Sujuan Zhuang,Xibing
author_sort	Li,Xuan
title	Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
title_short	Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
title_full	Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
title_fullStr	Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
title_full_unstemmed	Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
title_sort	effects of cpg oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100008
work_keys_str_mv	AT lixuan effectsofcpgoligodeoxynucleotide1826onacuteradiationinducedlunginjuryinmice AT xuguoxiong effectsofcpgoligodeoxynucleotide1826onacuteradiationinducedlunginjuryinmice AT qiaotiankui effectsofcpgoligodeoxynucleotide1826onacuteradiationinducedlunginjuryinmice AT yuansujuan effectsofcpgoligodeoxynucleotide1826onacuteradiationinducedlunginjuryinmice AT zhuangxibing effectsofcpgoligodeoxynucleotide1826onacuteradiationinducedlunginjuryinmice
_version_	1718441548070256640

Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice

Ejemplares similares