Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease

The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Iturriaga,Rodrigo, Del Rio,Rodrigo, Idiaquez,Juan, Somers,Virend K.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Autonomic dysfunction Carotid body Heart failure Metabolic syndrome Obstructive sleep apnea Sympathetic activation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602016000100013
record_format	dspace
spelling	oai:scielo:S0716-976020160001000132016-12-01Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic diseaseIturriaga,RodrigoDel Rio,RodrigoIdiaquez,JuanSomers,Virend K. Autonomic dysfunction Carotid body Heart failure Metabolic syndrome Obstructive sleep apnea Sympathetic activation The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100013en10.1186/s40659-016-0073-8
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Autonomic dysfunction Carotid body Heart failure Metabolic syndrome Obstructive sleep apnea Sympathetic activation
spellingShingle	Autonomic dysfunction Carotid body Heart failure Metabolic syndrome Obstructive sleep apnea Sympathetic activation Iturriaga,Rodrigo Del Rio,Rodrigo Idiaquez,Juan Somers,Virend K. Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
description	The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
author	Iturriaga,Rodrigo Del Rio,Rodrigo Idiaquez,Juan Somers,Virend K.
author_facet	Iturriaga,Rodrigo Del Rio,Rodrigo Idiaquez,Juan Somers,Virend K.
author_sort	Iturriaga,Rodrigo
title	Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
title_short	Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
title_full	Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
title_fullStr	Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
title_full_unstemmed	Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
title_sort	carotid body (thermoreceptors, sympathetic neural activation, and cardiometabolic disease
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100013
work_keys_str_mv	AT iturriagarodrigo carotidbodythermoreceptorssympatheticneuralactivationandcardiometabolicdisease AT delriorodrigo carotidbodythermoreceptorssympatheticneuralactivationandcardiometabolicdisease AT idiaquezjuan carotidbodythermoreceptorssympatheticneuralactivationandcardiometabolicdisease AT somersvirendk carotidbodythermoreceptorssympatheticneuralactivationandcardiometabolicdisease
_version_	1718441549645217792

Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease

Ejemplares similares