Genetic variants associated with neurodegenerative Alzheimer disease in natural models

The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that sho...

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Autores principales:	Salazar,Claudia, Valdivia,Gonzalo, Ardiles,Álvaro O., Ewer,John, Palacios,Adrian G.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Degus Genome APP APOE
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100014
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spelling	oai:scielo:S0716-976020160001000142016-12-01Genetic variants associated with neurodegenerative Alzheimer disease in natural modelsSalazar,ClaudiaValdivia,GonzaloArdiles,Álvaro O.Ewer,JohnPalacios,Adrian G. Degus Genome APP APOE The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100014en10.1186/s40659-016-0072-9
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Degus Genome APP APOE
spellingShingle	Degus Genome APP APOE Salazar,Claudia Valdivia,Gonzalo Ardiles,Álvaro O. Ewer,John Palacios,Adrian G. Genetic variants associated with neurodegenerative Alzheimer disease in natural models
description	The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
author	Salazar,Claudia Valdivia,Gonzalo Ardiles,Álvaro O. Ewer,John Palacios,Adrian G.
author_facet	Salazar,Claudia Valdivia,Gonzalo Ardiles,Álvaro O. Ewer,John Palacios,Adrian G.
author_sort	Salazar,Claudia
title	Genetic variants associated with neurodegenerative Alzheimer disease in natural models
title_short	Genetic variants associated with neurodegenerative Alzheimer disease in natural models
title_full	Genetic variants associated with neurodegenerative Alzheimer disease in natural models
title_fullStr	Genetic variants associated with neurodegenerative Alzheimer disease in natural models
title_full_unstemmed	Genetic variants associated with neurodegenerative Alzheimer disease in natural models
title_sort	genetic variants associated with neurodegenerative alzheimer disease in natural models
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100014
work_keys_str_mv	AT salazarclaudia geneticvariantsassociatedwithneurodegenerativealzheimerdiseaseinnaturalmodels AT valdiviagonzalo geneticvariantsassociatedwithneurodegenerativealzheimerdiseaseinnaturalmodels AT ardilesalvaroo geneticvariantsassociatedwithneurodegenerativealzheimerdiseaseinnaturalmodels AT ewerjohn geneticvariantsassociatedwithneurodegenerativealzheimerdiseaseinnaturalmodels AT palaciosadriang geneticvariantsassociatedwithneurodegenerativealzheimerdiseaseinnaturalmodels
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Genetic variants associated with neurodegenerative Alzheimer disease in natural models

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