A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats
BACKGROUND: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high...
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Sociedad de Biología de Chile
2016
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oai:scielo:S0716-976020160001000152016-12-01A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of ratsSandoval-Salazar,CuauhtemocRamírez-Emiliano,JoelTrejo-Bahena,AuroraOviedo-Solís,Cecilia I.Solís-Ortiz,Martha Silvia Obesity GABA Frontal cortex Hippocampus High-fat diet BACKGROUND: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats RESULTS: The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats CONCLUSIONS: HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100015en10.1186/s40659-016-0075-6 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Obesity GABA Frontal cortex Hippocampus High-fat diet |
| spellingShingle |
Obesity GABA Frontal cortex Hippocampus High-fat diet Sandoval-Salazar,Cuauhtemoc Ramírez-Emiliano,Joel Trejo-Bahena,Aurora Oviedo-Solís,Cecilia I. Solís-Ortiz,Martha Silvia A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| description |
BACKGROUND: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats RESULTS: The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats CONCLUSIONS: HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior. |
| author |
Sandoval-Salazar,Cuauhtemoc Ramírez-Emiliano,Joel Trejo-Bahena,Aurora Oviedo-Solís,Cecilia I. Solís-Ortiz,Martha Silvia |
| author_facet |
Sandoval-Salazar,Cuauhtemoc Ramírez-Emiliano,Joel Trejo-Bahena,Aurora Oviedo-Solís,Cecilia I. Solís-Ortiz,Martha Silvia |
| author_sort |
Sandoval-Salazar,Cuauhtemoc |
| title |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| title_short |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| title_full |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| title_fullStr |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| title_full_unstemmed |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats |
| title_sort |
high-fat diet decreases gaba concentration in the frontal cortex and hippocampus of rats |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2016 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100015 |
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