MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity

BACKGROUND: Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying coronary heart disease (CHD). Thus, the defense systems against ROS are critical...

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Autores principales:	Souiden,Yosra, Mallouli,Hela, Meskhi,Salah, Chaabouni,Yassine, Rebai,Ahmed, Chéour,Foued, Mahdouani,Kacem
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Genetic polymorphism Coronary heart disease SOD activity GPx activity Total antioxidant status Atherosclerosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100022
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spelling	oai:scielo:S0716-976020160001000222016-12-01MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severitySouiden,YosraMallouli,HelaMeskhi,SalahChaabouni,YassineRebai,AhmedChéour,FouedMahdouani,Kacem Genetic polymorphism Coronary heart disease SOD activity GPx activity Total antioxidant status Atherosclerosis BACKGROUND: Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying coronary heart disease (CHD). Thus, the defense systems against ROS are critical protecting blood vessel walls against oxidative damage. In this study, we investigate whether Ala16Val MnSOD and Pro198Leu GPx polymorphisms are associated with CHD susceptibility and/or severity METHODS: Both polymorphisms were genotyped in a sample of 203 controls and 164 patients. CHD risk and severity, antioxidant status (enzymatic and/or non enzymatic) and biochemical parameters were assessed and analysed by genotype RESULTS: A significant association of MnSOD variant to CHD risk was revealed in males. Males harboring the Val/Val genotype were approximately at twofold increased risk of CHD compared to controls (Ala carriers vs Val/Val, adjusted OR 1.89; 95 % CI 1.18-3.42, p = 0.03). Significant decreases in SOD activity and total antioxidant status (TAS) were observed in Val carriers and by CHD status. Whereas, no association of GPx variant genotype (Leu/Leu) and activity to cardiopathy events was discerned. CHD severity, as demonstrated by the number of vessel stenosis, was associated with significantly higher frequency of Val allele and LDL levels in CHD subjects CONCLUSIONS: Our results showed a lack of association of Pro198Leu GPx polymorphism to CHD risk and severity. However, they suggest that Ala16Val MnSOD polymorphism and decreased antioxidant defences are likely contributed to CHD risk in Tunisian men. Furthermore, the Val encoding MnSOD allele and decreased SOD activity were significantly correlated with CHD stenosis progressioninfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100022en10.1186/s40659-016-0083-6
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Genetic polymorphism Coronary heart disease SOD activity GPx activity Total antioxidant status Atherosclerosis
spellingShingle	Genetic polymorphism Coronary heart disease SOD activity GPx activity Total antioxidant status Atherosclerosis Souiden,Yosra Mallouli,Hela Meskhi,Salah Chaabouni,Yassine Rebai,Ahmed Chéour,Foued Mahdouani,Kacem MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
description	BACKGROUND: Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying coronary heart disease (CHD). Thus, the defense systems against ROS are critical protecting blood vessel walls against oxidative damage. In this study, we investigate whether Ala16Val MnSOD and Pro198Leu GPx polymorphisms are associated with CHD susceptibility and/or severity METHODS: Both polymorphisms were genotyped in a sample of 203 controls and 164 patients. CHD risk and severity, antioxidant status (enzymatic and/or non enzymatic) and biochemical parameters were assessed and analysed by genotype RESULTS: A significant association of MnSOD variant to CHD risk was revealed in males. Males harboring the Val/Val genotype were approximately at twofold increased risk of CHD compared to controls (Ala carriers vs Val/Val, adjusted OR 1.89; 95 % CI 1.18-3.42, p = 0.03). Significant decreases in SOD activity and total antioxidant status (TAS) were observed in Val carriers and by CHD status. Whereas, no association of GPx variant genotype (Leu/Leu) and activity to cardiopathy events was discerned. CHD severity, as demonstrated by the number of vessel stenosis, was associated with significantly higher frequency of Val allele and LDL levels in CHD subjects CONCLUSIONS: Our results showed a lack of association of Pro198Leu GPx polymorphism to CHD risk and severity. However, they suggest that Ala16Val MnSOD polymorphism and decreased antioxidant defences are likely contributed to CHD risk in Tunisian men. Furthermore, the Val encoding MnSOD allele and decreased SOD activity were significantly correlated with CHD stenosis progression
author	Souiden,Yosra Mallouli,Hela Meskhi,Salah Chaabouni,Yassine Rebai,Ahmed Chéour,Foued Mahdouani,Kacem
author_facet	Souiden,Yosra Mallouli,Hela Meskhi,Salah Chaabouni,Yassine Rebai,Ahmed Chéour,Foued Mahdouani,Kacem
author_sort	Souiden,Yosra
title	MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
title_short	MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
title_full	MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
title_fullStr	MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
title_full_unstemmed	MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity
title_sort	mnsod and gpx1 polymorphism relationship with coronary heart disease risk and severity
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100022
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MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity

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