Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the...

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Autores principales:	Wang,Min, Yan,Jingjun, He,Xingxing, Zhong,Qiang, Zhan,Chengye, Li,Shusheng
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Acute respiratory distress syndrome Sepsis Differentially expressed mRNAs Functional enrichment analysis Pathway analysis Transcription factors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100025
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spelling	oai:scielo:S0716-976020160001000252016-12-01Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profileWang,MinYan,JingjunHe,XingxingZhong,QiangZhan,ChengyeLi,Shusheng Acute respiratory distress syndrome Sepsis Differentially expressed mRNAs Functional enrichment analysis Pathway analysis Transcription factors BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS RESULTS: A total of 122 up-regulated DEGs and 91 down-regulated differentially expressed genes (DEGs) were obtained. The up- and down-regulated DEGs were mainly involved in functions like mitotic cell cycle and pathway like cell cycle. Protein-protein interaction network of ARDS analysis revealed 20 hub genes including cyclin B1 (CCNB1), cyclin B2 (CCNB2) and topoisomerase II alpha (TOP2A). A total of seven transcription factors including forkhead box protein M1 (FOXM1) and 30 target genes were revealed in the transcription factor-target gene regulation network. Furthermore, co-cited genes including CCNB2-CCNB1 were revealed in literature mining for the relations ARDS related genes CONCLUSIONS: Pathways like mitotic cell cycle were closed related with the development of ARDS. Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDSinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100025en10.1186/S40659-016-0085-4
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Acute respiratory distress syndrome Sepsis Differentially expressed mRNAs Functional enrichment analysis Pathway analysis Transcription factors
spellingShingle	Acute respiratory distress syndrome Sepsis Differentially expressed mRNAs Functional enrichment analysis Pathway analysis Transcription factors Wang,Min Yan,Jingjun He,Xingxing Zhong,Qiang Zhan,Chengye Li,Shusheng Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
description	BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS RESULTS: A total of 122 up-regulated DEGs and 91 down-regulated differentially expressed genes (DEGs) were obtained. The up- and down-regulated DEGs were mainly involved in functions like mitotic cell cycle and pathway like cell cycle. Protein-protein interaction network of ARDS analysis revealed 20 hub genes including cyclin B1 (CCNB1), cyclin B2 (CCNB2) and topoisomerase II alpha (TOP2A). A total of seven transcription factors including forkhead box protein M1 (FOXM1) and 30 target genes were revealed in the transcription factor-target gene regulation network. Furthermore, co-cited genes including CCNB2-CCNB1 were revealed in literature mining for the relations ARDS related genes CONCLUSIONS: Pathways like mitotic cell cycle were closed related with the development of ARDS. Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS
author	Wang,Min Yan,Jingjun He,Xingxing Zhong,Qiang Zhan,Chengye Li,Shusheng
author_facet	Wang,Min Yan,Jingjun He,Xingxing Zhong,Qiang Zhan,Chengye Li,Shusheng
author_sort	Wang,Min
title	Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
title_short	Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
title_full	Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
title_fullStr	Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
title_full_unstemmed	Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
title_sort	candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100025
work_keys_str_mv	AT wangmin candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile AT yanjingjun candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile AT hexingxing candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile AT zhongqiang candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile AT zhanchengye candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile AT lishusheng candidategenesandpathogenesisinvestigationforsepsisrelatedacuterespiratorydistresssyndromebasedongeneexpressionprofile
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Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile

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