Protective roles of free avian respiratory macrophages in captive birds

In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth of the cells in the avian lung has been purported to foreordain a weak fi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mutua,Mbuvi P., Muya,Shadrack, Gicheru,Muita M.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Avian lung FARM Phagocytosis PPAR γ ligands
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100029
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602016000100029
record_format	dspace
spelling	oai:scielo:S0716-976020160001000292016-12-01Protective roles of free avian respiratory macrophages in captive birdsMutua,Mbuvi P.Muya,ShadrackGicheru,Muita M. Avian lung FARM Phagocytosis PPAR γ ligands In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth of the cells in the avian lung has been purported to foreordain a weak first line of pulmonary defense, a condition associated with high mortality of domestic birds occasioned by respiratory inflictions. Avian pulmonary mechanisms including a three tiered aerodynamic filtration system, tight epithelial junctions and an efficient mucociliary escalator system have been known to supplement FARM protective roles. Current studies, however, report FARM to exhibit an exceptionally efficient phagocytic capacity and are effective in elimination of invading pathogens. In this review, we also report on effects of selective synthetic peroxisome proliferator activated receptor gamma (PPAR γ) agonists on non phlogistic phagocytic properties in the FARM. To develop effective therapeutic interventions targeting FARM in treatment and management of respiratory disease conditions in the poultry, further studies are required to fully understand the role of FARM in innate and adaptive immune responses.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100029en10.1186/S40659-016-0090-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Avian lung FARM Phagocytosis PPAR γ ligands
spellingShingle	Avian lung FARM Phagocytosis PPAR γ ligands Mutua,Mbuvi P. Muya,Shadrack Gicheru,Muita M. Protective roles of free avian respiratory macrophages in captive birds
description	In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth of the cells in the avian lung has been purported to foreordain a weak first line of pulmonary defense, a condition associated with high mortality of domestic birds occasioned by respiratory inflictions. Avian pulmonary mechanisms including a three tiered aerodynamic filtration system, tight epithelial junctions and an efficient mucociliary escalator system have been known to supplement FARM protective roles. Current studies, however, report FARM to exhibit an exceptionally efficient phagocytic capacity and are effective in elimination of invading pathogens. In this review, we also report on effects of selective synthetic peroxisome proliferator activated receptor gamma (PPAR γ) agonists on non phlogistic phagocytic properties in the FARM. To develop effective therapeutic interventions targeting FARM in treatment and management of respiratory disease conditions in the poultry, further studies are required to fully understand the role of FARM in innate and adaptive immune responses.
author	Mutua,Mbuvi P. Muya,Shadrack Gicheru,Muita M.
author_facet	Mutua,Mbuvi P. Muya,Shadrack Gicheru,Muita M.
author_sort	Mutua,Mbuvi P.
title	Protective roles of free avian respiratory macrophages in captive birds
title_short	Protective roles of free avian respiratory macrophages in captive birds
title_full	Protective roles of free avian respiratory macrophages in captive birds
title_fullStr	Protective roles of free avian respiratory macrophages in captive birds
title_full_unstemmed	Protective roles of free avian respiratory macrophages in captive birds
title_sort	protective roles of free avian respiratory macrophages in captive birds
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100029
work_keys_str_mv	AT mutuambuvip protectiverolesoffreeavianrespiratorymacrophagesincaptivebirds AT muyashadrack protectiverolesoffreeavianrespiratorymacrophagesincaptivebirds AT gicherumuitam protectiverolesoffreeavianrespiratorymacrophagesincaptivebirds
_version_	1718441553968496640

Protective roles of free avian respiratory macrophages in captive birds

Ejemplares similares