Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats

BACKGROUND: Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature RESULTS: In this...

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Autores principales:	Cao,Xuebing, Hou,Dongzhi, Wang,Lei, Li,Sai, Sun,Shengang, Ping,Qineng, Xu,Yan
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Dyskinesia Levodopa liposomes ERK1/2 DARPP-32 FosB/AFosB
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100032
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spelling	oai:scielo:S0716-976020160001000322016-12-01Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia ratsCao,XuebingHou,DongzhiWang,LeiLi,SaiSun,ShengangPing,QinengXu,Yan Dyskinesia Levodopa liposomes ERK1/2 DARPP-32 FosB/AFosB BACKGROUND: Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature RESULTS: In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phos-phoprotein of 32 kDa (DARPP-32) and FosB/AFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P < 0.05), compared with levodopa group. Levels of phospho-ERK1/2, phospho-Thr34 DARPP-32 and FosB/AFosB in striatum decreased significantly in liposome group lesion side compared with levodopa group (P < 0.05). However, both of two groups above have significantly differences compared with the control group (P < 0.05 CONCLUSION: Chitosan-coated levodopa liposomes may be useful in reducing dyskinesias inducing for Parkinson disease. The mechanism might be involved the pathway of signaling molecular phospho-ERK1/2, phospho-Thr34 DARPP-32 and AFosB in striatuminfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100032en10.1186/s40659-016-0093-4
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Dyskinesia Levodopa liposomes ERK1/2 DARPP-32 FosB/AFosB
spellingShingle	Dyskinesia Levodopa liposomes ERK1/2 DARPP-32 FosB/AFosB Cao,Xuebing Hou,Dongzhi Wang,Lei Li,Sai Sun,Shengang Ping,Qineng Xu,Yan Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
description	BACKGROUND: Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature RESULTS: In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phos-phoprotein of 32 kDa (DARPP-32) and FosB/AFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P < 0.05), compared with levodopa group. Levels of phospho-ERK1/2, phospho-Thr34 DARPP-32 and FosB/AFosB in striatum decreased significantly in liposome group lesion side compared with levodopa group (P < 0.05). However, both of two groups above have significantly differences compared with the control group (P < 0.05 CONCLUSION: Chitosan-coated levodopa liposomes may be useful in reducing dyskinesias inducing for Parkinson disease. The mechanism might be involved the pathway of signaling molecular phospho-ERK1/2, phospho-Thr34 DARPP-32 and AFosB in striatum
author	Cao,Xuebing Hou,Dongzhi Wang,Lei Li,Sai Sun,Shengang Ping,Qineng Xu,Yan
author_facet	Cao,Xuebing Hou,Dongzhi Wang,Lei Li,Sai Sun,Shengang Ping,Qineng Xu,Yan
author_sort	Cao,Xuebing
title	Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
title_short	Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
title_full	Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
title_fullStr	Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
title_full_unstemmed	Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
title_sort	effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100032
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Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats

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