Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence induction. Recently, we determine...

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Autores principales: Marthandan,Shiva, Menzel,Uwe, Priebe,Steffen, Groth,Marco, Guthke,Reinhard, Platzer,Matthias, Hemmerich,Peter, Kaether,Christoph, Diekmann,Stephan
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2016
Materias:
Senescence
Fibroblasts
γ-irradiation
Aging
Transcriptome analysis
DNA repair
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100034
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