Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model

BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited p...

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Autores principales:	Hwan-Hee,Jang, Su-Yeon,Cho, Mi-Ju,Kim, Jung-Bong,Kim, Sung-Hyen,Lee, Mee-Young,Lee, Young-Min,Lee
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2016
Materias:	Anti-inflammatory Asthma Salvia plebeia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041
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spelling	oai:scielo:S0716-976020160001000412016-12-01Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse modelHwan-Hee,JangSu-Yeon,ChoMi-Ju,KimJung-Bong,KimSung-Hyen,LeeMee-Young,LeeYoung-Min,Lee Anti-inflammatory Asthma Salvia plebeia BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone CONCLUSIONS: Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthmainfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041en10.1186/s40659-016-0102-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Anti-inflammatory Asthma Salvia plebeia
spellingShingle	Anti-inflammatory Asthma Salvia plebeia Hwan-Hee,Jang Su-Yeon,Cho Mi-Ju,Kim Jung-Bong,Kim Sung-Hyen,Lee Mee-Young,Lee Young-Min,Lee Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
description	BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone CONCLUSIONS: Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthma
author	Hwan-Hee,Jang Su-Yeon,Cho Mi-Ju,Kim Jung-Bong,Kim Sung-Hyen,Lee Mee-Young,Lee Young-Min,Lee
author_facet	Hwan-Hee,Jang Su-Yeon,Cho Mi-Ju,Kim Jung-Bong,Kim Sung-Hyen,Lee Mee-Young,Lee Young-Min,Lee
author_sort	Hwan-Hee,Jang
title	Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
title_short	Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
title_full	Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
title_fullStr	Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
title_full_unstemmed	Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
title_sort	anti-inflammatory effects of salvia plebeia r. br extract in vitro and in ovalbumin-induced mouse model
publisher	Sociedad de Biología de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041
work_keys_str_mv	AT hwanheejang antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT suyeoncho antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT mijukim antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT jungbongkim antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT sunghyenlee antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT meeyounglee antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel AT youngminlee antiinflammatoryeffectsofsalviaplebeiarbrextractinvitroandinovalbumininducedmousemodel
_version_	1718441557281996800

Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model

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