Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis
BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cel...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2016
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oai:scielo:S0716-976020160001000422016-12-01Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasisWang,HuiLiu,ZhengZhang,WenxiuYuan,ZiaoYuan,HongyiLiu,XuetingYang,ChunwenGuan,Weijun Siberian tiger Cadmium Apoptosis Fibroblast Calcium BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cell types and tissues. RESULTS: We investigated the apoptotic effects of Cd2+ on Siberian tiger fibroblasts in vitro. Our research revealed the typical signs of apoptosis after Cd²+ exposure. Apoptosis was dose- (0-4.8 μΜ) and duration-dependent (12-48 h), and proliferation was strongly inhibited. Cd²+ increased the activity of caspase-3, -8, and -9 and disrupted calcium homeostasis by causing oxidative stress and mitochondrial dysfunction. It also increased K+ efflux and altered the mRNA levels of Bax, Bcl-2, caspase-3, caspase-8, Fas, and p53. CONCLUSIONS: Our results suggest that Cd2+ triggers the apoptosis of Siberian tiger fibroblasts by disturbing intracellular homeostasis. These results will aid in our understanding of the effects of Cd2+ on Siberian tigers and in developing interventions to treat and prevent cadmium poisoning.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.49 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100042en10.1186/s40659-016-0103-6 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Siberian tiger Cadmium Apoptosis Fibroblast Calcium |
| spellingShingle |
Siberian tiger Cadmium Apoptosis Fibroblast Calcium Wang,Hui Liu,Zheng Zhang,Wenxiu Yuan,Ziao Yuan,Hongyi Liu,Xueting Yang,Chunwen Guan,Weijun Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| description |
BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cell types and tissues. RESULTS: We investigated the apoptotic effects of Cd2+ on Siberian tiger fibroblasts in vitro. Our research revealed the typical signs of apoptosis after Cd²+ exposure. Apoptosis was dose- (0-4.8 μΜ) and duration-dependent (12-48 h), and proliferation was strongly inhibited. Cd²+ increased the activity of caspase-3, -8, and -9 and disrupted calcium homeostasis by causing oxidative stress and mitochondrial dysfunction. It also increased K+ efflux and altered the mRNA levels of Bax, Bcl-2, caspase-3, caspase-8, Fas, and p53. CONCLUSIONS: Our results suggest that Cd2+ triggers the apoptosis of Siberian tiger fibroblasts by disturbing intracellular homeostasis. These results will aid in our understanding of the effects of Cd2+ on Siberian tigers and in developing interventions to treat and prevent cadmium poisoning. |
| author |
Wang,Hui Liu,Zheng Zhang,Wenxiu Yuan,Ziao Yuan,Hongyi Liu,Xueting Yang,Chunwen Guan,Weijun |
| author_facet |
Wang,Hui Liu,Zheng Zhang,Wenxiu Yuan,Ziao Yuan,Hongyi Liu,Xueting Yang,Chunwen Guan,Weijun |
| author_sort |
Wang,Hui |
| title |
Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| title_short |
Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| title_full |
Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| title_fullStr |
Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| title_full_unstemmed |
Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| title_sort |
cadmium-induced apoptosis of siberian tiger fibroblasts via disrupted intracellular homeostasis |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2016 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100042 |
| work_keys_str_mv |
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