Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney

Abstract Background A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective...

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Autores principales:	Du,Guankui, Xiao,Man, Zhang,Xuezi, Wen,Maoyu, Pang,Chi, Jiang,Shangfei, Sang,Shenggang, Xie,Yiqiang
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2017
Materias:	miRNA db-/db- mice Alpinia oxyphylla Miq Kidney Diabetic nephropathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100206
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spelling	oai:scielo:S0716-976020170001002062017-04-10Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidneyDu,GuankuiXiao,ManZhang,XueziWen,MaoyuPang,ChiJiang,ShangfeiSang,ShenggangXie,Yiqiang miRNA db-/db- mice Alpinia oxyphylla Miq Kidney Diabetic nephropathy Abstract Background A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective of this study was to detect the alteration of miRNAs underlying the anti-diabetes effects of A. oxyphylla extract (AOE) in a type II diabetic animal model (C57BIKsj db-/db-). Results Treatment with AOE for 8 weeks led to lower concentrations of blood glucose, urine albumin, and urine creatinine. 17 and 13 miRNAs were statistically identified as differentially regulated in the DB/DB and db-/db- AOE mice, respectively, compared to the untreated db-/db- mice. Of these, 7 miRNAs were identified in both comparison groups, and these 7 miRNAs were verified by quantitative real-time PCR. Functional bioinformatics showed that the putative target genes of 7 miRNAs were associated with several diabetes effects and signaling pathways. Conclusions These founding suggest that the potential of AOE as a medicinal anti-diabetes treatment through changes in the expressions of specific miRNAs. The results provide a useful resource for future investigation of the role of AOE-regulated miRNAs in diabetes mellitus.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.50 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100206en10.1186/s40659-017-0111-1
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	miRNA db-/db- mice Alpinia oxyphylla Miq Kidney Diabetic nephropathy
spellingShingle	miRNA db-/db- mice Alpinia oxyphylla Miq Kidney Diabetic nephropathy Du,Guankui Xiao,Man Zhang,Xuezi Wen,Maoyu Pang,Chi Jiang,Shangfei Sang,Shenggang Xie,Yiqiang Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
description	Abstract Background A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective of this study was to detect the alteration of miRNAs underlying the anti-diabetes effects of A. oxyphylla extract (AOE) in a type II diabetic animal model (C57BIKsj db-/db-). Results Treatment with AOE for 8 weeks led to lower concentrations of blood glucose, urine albumin, and urine creatinine. 17 and 13 miRNAs were statistically identified as differentially regulated in the DB/DB and db-/db- AOE mice, respectively, compared to the untreated db-/db- mice. Of these, 7 miRNAs were identified in both comparison groups, and these 7 miRNAs were verified by quantitative real-time PCR. Functional bioinformatics showed that the putative target genes of 7 miRNAs were associated with several diabetes effects and signaling pathways. Conclusions These founding suggest that the potential of AOE as a medicinal anti-diabetes treatment through changes in the expressions of specific miRNAs. The results provide a useful resource for future investigation of the role of AOE-regulated miRNAs in diabetes mellitus.
author	Du,Guankui Xiao,Man Zhang,Xuezi Wen,Maoyu Pang,Chi Jiang,Shangfei Sang,Shenggang Xie,Yiqiang
author_facet	Du,Guankui Xiao,Man Zhang,Xuezi Wen,Maoyu Pang,Chi Jiang,Shangfei Sang,Shenggang Xie,Yiqiang
author_sort	Du,Guankui
title	Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
title_short	Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
title_full	Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
title_fullStr	Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
title_full_unstemmed	Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
title_sort	alpinia oxyphylla miq. extract changes mirna expression profiles in db-/db- mouse kidney
publisher	Sociedad de Biología de Chile
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100206
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Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney

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