Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation

Abstract Background The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation an...

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Autores principales:	Mamun,Md. Abdullah Al, Hosen,Mohammad Jakir, Khatun,Amina, Alam,M. Masihul, Al-Bari,Md. Abdul Alim
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2017
Materias:	Alkaline phosphatase Bone formation Osteoblast differentiation Tridax procumbens flavonoids Trabecular bone
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100221
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spelling	oai:scielo:S0716-976020170001002212017-11-03Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formationMamun,Md. Abdullah AlHosen,Mohammad JakirKhatun,AminaAlam,M. MasihulAl-Bari,Md. Abdul Alim Alkaline phosphatase Bone formation Osteoblast differentiation Tridax procumbens flavonoids Trabecular bone Abstract Background The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear. In this study, we investigated the effects of the TPF on in vivo bone formation, injected the TPF (20 mg/kg) twice a day in the low calcium diet mice and killed them after 21 day. Radiographic and histomorphometric analyses were performed on the dissected bones to determine the anabolic effects of the TPF. Results Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. Conclusion Our findings point towards the stimulation of bone formation by TPF, suggested that the TPF could be a potential natural anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.50 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100221en10.1186/s40659-017-0134-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alkaline phosphatase Bone formation Osteoblast differentiation Tridax procumbens flavonoids Trabecular bone
spellingShingle	Alkaline phosphatase Bone formation Osteoblast differentiation Tridax procumbens flavonoids Trabecular bone Mamun,Md. Abdullah Al Hosen,Mohammad Jakir Khatun,Amina Alam,M. Masihul Al-Bari,Md. Abdul Alim Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
description	Abstract Background The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear. In this study, we investigated the effects of the TPF on in vivo bone formation, injected the TPF (20 mg/kg) twice a day in the low calcium diet mice and killed them after 21 day. Radiographic and histomorphometric analyses were performed on the dissected bones to determine the anabolic effects of the TPF. Results Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. Conclusion Our findings point towards the stimulation of bone formation by TPF, suggested that the TPF could be a potential natural anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.
author	Mamun,Md. Abdullah Al Hosen,Mohammad Jakir Khatun,Amina Alam,M. Masihul Al-Bari,Md. Abdul Alim
author_facet	Mamun,Md. Abdullah Al Hosen,Mohammad Jakir Khatun,Amina Alam,M. Masihul Al-Bari,Md. Abdul Alim
author_sort	Mamun,Md. Abdullah Al
title	Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
title_short	Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
title_full	Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
title_fullStr	Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
title_full_unstemmed	Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
title_sort	tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
publisher	Sociedad de Biología de Chile
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100221
work_keys_str_mv	AT mamunmdabdullahal tridaxprocumbensflavonoidsaprospectivebioactivecompoundincreasedosteoblastdifferentiationandtrabecularboneformation AT hosenmohammadjakir tridaxprocumbensflavonoidsaprospectivebioactivecompoundincreasedosteoblastdifferentiationandtrabecularboneformation AT khatunamina tridaxprocumbensflavonoidsaprospectivebioactivecompoundincreasedosteoblastdifferentiationandtrabecularboneformation AT alammmasihul tridaxprocumbensflavonoidsaprospectivebioactivecompoundincreasedosteoblastdifferentiationandtrabecularboneformation AT albarimdabdulalim tridaxprocumbensflavonoidsaprospectivebioactivecompoundincreasedosteoblastdifferentiationandtrabecularboneformation
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Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation

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