Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer

Abstract Background Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim...

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Autores principales:	Shen,Xiaogang, Bai,Yifeng, Luo,Bin, Zhou,Xiaogang
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2017
Materias:	lncRNA BANCR Colorectal cancer Lymph node metastasis Prognosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100223
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spelling	oai:scielo:S0716-976020170001002232017-11-03Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancerShen,XiaogangBai,YifengLuo,BinZhou,Xiaogang lncRNA BANCR Colorectal cancer Lymph node metastasis Prognosis Abstract Background Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients. Methods The expression of lncRNA BANCR was measured in 106 CRC tissues and 65 adjacent normal tissues using the quantitative real-time PCR. Results The study showed that lncRNA BANCR was highly expressed in CRC tissues compared with adjacent normal tissues (P < 0.001). In addition, high expression of lncRNA BANCR was positively correlated with the lymph node metastasis (P < 0.001). Kaplan–Meier analysis showed that patients with high lncRNA BANCR expression had a shorter overall survival (OS) compared with the low lncRNA BANCR expression group (P = 0.001). Interestingly, for the group of patients with the lymph node metastasis, we found the similar result that high lncRNA BANCR expression was related to poor OS (P = 0.004). Furthermore, the multivariate Cox regression model analysis indicated that high expression of lncRNA BANCR was an independent poor prognostic factor in CRC patients (HR 2.24, 95% CI 1.22–4.16, P = 0.009). Conclusions Upregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of CRC. LncRNA BANCR could be served as a novel and useful biomarker for CRC lymph node metastasis and prognosis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.50 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100223en10.1186/s40659-017-0136-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	lncRNA BANCR Colorectal cancer Lymph node metastasis Prognosis
spellingShingle	lncRNA BANCR Colorectal cancer Lymph node metastasis Prognosis Shen,Xiaogang Bai,Yifeng Luo,Bin Zhou,Xiaogang Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
description	Abstract Background Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients. Methods The expression of lncRNA BANCR was measured in 106 CRC tissues and 65 adjacent normal tissues using the quantitative real-time PCR. Results The study showed that lncRNA BANCR was highly expressed in CRC tissues compared with adjacent normal tissues (P < 0.001). In addition, high expression of lncRNA BANCR was positively correlated with the lymph node metastasis (P < 0.001). Kaplan–Meier analysis showed that patients with high lncRNA BANCR expression had a shorter overall survival (OS) compared with the low lncRNA BANCR expression group (P = 0.001). Interestingly, for the group of patients with the lymph node metastasis, we found the similar result that high lncRNA BANCR expression was related to poor OS (P = 0.004). Furthermore, the multivariate Cox regression model analysis indicated that high expression of lncRNA BANCR was an independent poor prognostic factor in CRC patients (HR 2.24, 95% CI 1.22–4.16, P = 0.009). Conclusions Upregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of CRC. LncRNA BANCR could be served as a novel and useful biomarker for CRC lymph node metastasis and prognosis.
author	Shen,Xiaogang Bai,Yifeng Luo,Bin Zhou,Xiaogang
author_facet	Shen,Xiaogang Bai,Yifeng Luo,Bin Zhou,Xiaogang
author_sort	Shen,Xiaogang
title	Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
title_short	Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
title_full	Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
title_fullStr	Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
title_full_unstemmed	Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer
title_sort	upregulation of lncrna bancr associated with the lymph node metastasis and poor prognosis in colorectal cancer
publisher	Sociedad de Biología de Chile
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100223
work_keys_str_mv	AT shenxiaogang upregulationoflncrnabancrassociatedwiththelymphnodemetastasisandpoorprognosisincolorectalcancer AT baiyifeng upregulationoflncrnabancrassociatedwiththelymphnodemetastasisandpoorprognosisincolorectalcancer AT luobin upregulationoflncrnabancrassociatedwiththelymphnodemetastasisandpoorprognosisincolorectalcancer AT zhouxiaogang upregulationoflncrnabancrassociatedwiththelymphnodemetastasisandpoorprognosisincolorectalcancer
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Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer

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