Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma

Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We...

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Autores principales:	Xing,Haijie, Chen,Xiangdong, Han,Yaofeng
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2017
Materias:	Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100227
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spelling	oai:scielo:S0716-976020170001002272018-01-08Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinomaXing,HaijieChen,XiangdongHan,Yaofeng Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients. Conclusion REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.50 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100227en10.1186/s40659-017-0142-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival
spellingShingle	Nasopharyngeal carcinoma Regenerating gene IA Invasion Survival Xing,Haijie Chen,Xiangdong Han,Yaofeng Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
description	Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients. Conclusion REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.
author	Xing,Haijie Chen,Xiangdong Han,Yaofeng
author_facet	Xing,Haijie Chen,Xiangdong Han,Yaofeng
author_sort	Xing,Haijie
title	Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
title_short	Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
title_full	Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
title_fullStr	Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
title_full_unstemmed	Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
title_sort	role of regenerating gene ia expression on local invasion and survival in nasopharyngeal carcinoma
publisher	Sociedad de Biología de Chile
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100227
work_keys_str_mv	AT xinghaijie roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma AT chenxiangdong roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma AT hanyaofeng roleofregeneratinggeneiaexpressiononlocalinvasionandsurvivalinnasopharyngealcarcinoma
_version_	1718441564606300160

Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma

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