Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Abstract Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetrasulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. fer...

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Autores principales:	Chen,Peng, Xu,Ruixiang, Yan,Lei, Wu,Zhengrong, Wei,Yan, Zhao,Wenbin, Wang,Xin, Xie,Qinjian, Li,Hongyu
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2017
Materias:	A. ferrooxidans Anticancer effect Bioleaching RBS Realgar
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100502
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spelling	oai:scielo:S0716-976020170001005022017-06-14Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agentChen,PengXu,RuixiangYan,LeiWu,ZhengrongWei,YanZhao,WenbinWang,XinXie,QinjianLi,Hongyu A. ferrooxidans Anticancer effect Bioleaching RBS Realgar Abstract Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetrasulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation. The present systematic review reports on the research progress in realgar bioleaching and its antitumor mechanism as an anticancer agent. A total of 93 research articles that report on the biological activity of extracts from realgar using bacteria and its preparation were presented in this review. The realgar bioleaching solution (RBS) works by inducing apoptosis when it is used to treat tumor cells in vitro and in vivo. When it is used to treat animal model organisms in vivo, such as mice and Caenorhabditis elegans, tumor tissues grew more slowly, with mass necrosis. Meanwhile, the agent also showed obvious inhibition of tumor cell growth. Bioleaching technology greatly improves the utilization of realgar and is a novel methodology to improve the traditional method.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.50 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100502en10.1186/s40659-017-0122-y
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	A. ferrooxidans Anticancer effect Bioleaching RBS Realgar
spellingShingle	A. ferrooxidans Anticancer effect Bioleaching RBS Realgar Chen,Peng Xu,Ruixiang Yan,Lei Wu,Zhengrong Wei,Yan Zhao,Wenbin Wang,Xin Xie,Qinjian Li,Hongyu Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
description	Abstract Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetrasulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation. The present systematic review reports on the research progress in realgar bioleaching and its antitumor mechanism as an anticancer agent. A total of 93 research articles that report on the biological activity of extracts from realgar using bacteria and its preparation were presented in this review. The realgar bioleaching solution (RBS) works by inducing apoptosis when it is used to treat tumor cells in vitro and in vivo. When it is used to treat animal model organisms in vivo, such as mice and Caenorhabditis elegans, tumor tissues grew more slowly, with mass necrosis. Meanwhile, the agent also showed obvious inhibition of tumor cell growth. Bioleaching technology greatly improves the utilization of realgar and is a novel methodology to improve the traditional method.
author	Chen,Peng Xu,Ruixiang Yan,Lei Wu,Zhengrong Wei,Yan Zhao,Wenbin Wang,Xin Xie,Qinjian Li,Hongyu
author_facet	Chen,Peng Xu,Ruixiang Yan,Lei Wu,Zhengrong Wei,Yan Zhao,Wenbin Wang,Xin Xie,Qinjian Li,Hongyu
author_sort	Chen,Peng
title	Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_short	Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_full	Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_fullStr	Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_full_unstemmed	Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_sort	properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
publisher	Sociedad de Biología de Chile
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100502
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Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

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